{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:36:41Z","timestamp":1791272201332,"version":"4.1.0"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>We investigated the susceptibility of 10 enterovirus D68 (EV-D68) isolates (belonging to clusters A, B, and C) to (entero)virus inhibitors with different mechanisms of action. The 3C-protease inhibitors proved to be more efficient than enviroxime and pleconaril, which in turn were more effective than vapendavir and pirodavir. Favipiravir proved to be a weak inhibitor. Resistance to pleconaril maps to V69A in the VP1 protein, and resistance to rupintrivir maps to V104I in the 3C protease. A structural explanation of why both substitutions may cause resistance is provided.<\/jats:p>","DOI":"10.1128\/aac.01375-15","type":"journal-article","created":{"date-parts":[[2015,9,15]],"date-time":"2015-09-15T01:51:14Z","timestamp":1442281874000},"page":"7782-7785","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":76,"title":["Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68"],"prefix":"10.1128","volume":"59","author":[{"given":"Liang","family":"Sun","sequence":"first","affiliation":[{"name":"KU Leuven \u2013 University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Meijer","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases Research, Diagnostics and Screening, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathy","family":"Froeyen","sequence":"additional","affiliation":[{"name":"Rega Institute for Medical Research, Laboratory of Medicinal Chemistry, University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of L\u00fcbeck, L\u00fcbeck, Germany"},{"name":"German Center for Infection Research (DZIF), University of L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik Jan","family":"Thibaut","sequence":"additional","affiliation":[{"name":"KU Leuven \u2013 University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium"},{"name":"Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Baggen","sequence":"additional","affiliation":[{"name":"Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyla","family":"George","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Vernachio","sequence":"additional","affiliation":[{"name":"Biota Pharmaceuticals, Alpharetta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J. M.","family":"van Kuppeveld","sequence":"additional","affiliation":[{"name":"Virology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Leyssen","sequence":"additional","affiliation":[{"name":"KU Leuven \u2013 University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf","family":"Hilgenfeld","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry, Center for Structural and Cell Biology in Medicine, University of L\u00fcbeck, L\u00fcbeck, Germany"},{"name":"German Center for Infection Research (DZIF), University of L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Neyts","sequence":"additional","affiliation":[{"name":"KU Leuven \u2013 University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leen","family":"Delang","sequence":"additional","affiliation":[{"name":"KU Leuven \u2013 University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2011.11.021"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.043935-0"},{"key":"e_1_3_2_4_2","doi-asserted-by":"crossref","unstructured":"Meijer A Benschop KS Donker GA van der Avoort HG. 2014. Continued seasonal circulation of enterovirus D68 in the Netherlands 2011-2014. Euro Surveill 19:pii=20935. http:\/\/www.eurosurveillance.org\/ViewArticle.aspx?ArticleId=20935.","DOI":"10.2807\/1560-7917.ES2014.19.42.20935"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201412-592FR"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.14248"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)70093-9"},{"key":"e_1_3_2_8_2","doi-asserted-by":"crossref","unstructured":"Pfeiffer HC Bragstad K Skram MK Dahl H Knudsen PK Chawla MS Holberg-Petersen M Vainio K Dudman SG Kran AM Rojahn AE. 2015. Two cases of acute severe flaccid myelitis associated with enterovirus D68 infection in children Norway autumn 2014. 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