{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T22:14:29Z","timestamp":1776204869161,"version":"3.50.1"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Acinetobacter baumannii<\/jats:named-content>\n            is an opportunistic pathogen that is an important source of nosocomial infections. Production of extended-spectrum \u03b2-lactamases (ESBLs) of the GES type in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">A. baumannii<\/jats:named-content>\n            has been increasingly reported, and some of these GES-type enzymes possess some carbapenemase activity. Our aim was to analyze the resistance determinants and the clonal relationships of carbapenem-nonsusceptible\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">A. baumannii<\/jats:named-content>\n            clinical isolates recovered from hospitals in Kuwait. A total of 63 isolates were analyzed, and all were found to be positive for\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>GES<\/jats:sub>\n            -type genes. One isolate harbored the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>GES-14<\/jats:sub>\n            gene encoding an ESBL with significant carbapenemase activity, whereas the other isolates harbored the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>GES-11<\/jats:sub>\n            ESBL gene. Thirty-three isolates coharbored the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>OXA-23<\/jats:sub>\n            and\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>GES-11<\/jats:sub>\n            genes. Analyses of the genetic locations indicated that the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>GES-11\/-14<\/jats:sub>\n            genes were plasmid located. It is noteworthy that the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>OXA-23<\/jats:sub>\n            and\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>GES-11<\/jats:sub>\n            genes were colocated onto a single plasmid. Nine different pulsotypes were observed among the 63 isolates. This study showed the emergence of GES-type ESBLs in\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">A. baumannii<\/jats:named-content>\n            in Kuwait, further suggesting that the Middle East region might be a reservoir for carbapenemase-producing\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">A. baumannii<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.01384-12","type":"journal-article","created":{"date-parts":[[2012,10,24]],"date-time":"2012-10-24T00:48:45Z","timestamp":1351039725000},"page":"183-188","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":73,"title":["Wide Dissemination of GES-Type Carbapenemases in Acinetobacter baumannii Isolates in Kuwait"],"prefix":"10.1128","volume":"57","author":[{"given":"R\u00e9my A.","family":"Bonnin","sequence":"first","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, H\u00f4pital de Bic\u00eatre, Assistance Publique\/H\u00f4pitaux de Paris, Facult\u00e9 de M\u00e9decine et Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent O.","family":"Rotimi","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Al Hubail","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"Gasiorowski","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, H\u00f4pital de Bic\u00eatre, Assistance Publique\/H\u00f4pitaux de Paris, Facult\u00e9 de M\u00e9decine et Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noura","family":"Al Sweih","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Medicine, Kuwait University, Safat, Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrice","family":"Nordmann","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, H\u00f4pital de Bic\u00eatre, Assistance Publique\/H\u00f4pitaux de Paris, Facult\u00e9 de M\u00e9decine et Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Poirel","sequence":"additional","affiliation":[{"name":"Service de Bact\u00e9riologie-Virologie, INSERM U914, Emerging Resistance to Antibiotics, H\u00f4pital de Bic\u00eatre, Assistance Publique\/H\u00f4pitaux de Paris, Facult\u00e9 de M\u00e9decine et Universit\u00e9 Paris-Sud, Le Kremlin-Bic\u00eatre, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-07"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/iub.532"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid1601.090852"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2012.02.008"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00871-10"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00773-10"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00072-09"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.3.622-632.2000"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1099\/00207713-47-3-837"},{"key":"e_1_3_3_11_2","volume-title":"Performance standards for antimicrobial susceptibility testing (M100-S22).","author":"Clinical and Laboratory Standards Institute","year":"2012","unstructured":"Clinical and Laboratory Standards Institute. 2012. Performance standards for antimicrobial susceptibility testing (M100-S22). Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06276-11"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2011.08.016"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00542-10"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0147-619X(84)90063-5"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.35.12.3071-3077.1997"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2007.01759.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010034"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01588-06"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06462-11"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01661-10"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00570-08"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03622.x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2010.10.018"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkp428"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2003.10.003"},{"key":"e_1_3_3_27_2","first-page":"318","article-title":"Molecular epidemiology and mechanisms of carbapenem-resistant Acinetobacter baumannii in a Saudi Arabia hospital (P1256)","volume":"18","author":"Ribeiro A","year":"2012","unstructured":"RibeiroA Al-AgamyMH ShiblAM TawfikAF CourvalinP JeannotK. 2012. Molecular epidemiology and mechanisms of carbapenem-resistant Acinetobacter baumannii in a Saudi Arabia hospital (P1256). Clin. Microbiol. Infect. 18:318.","journal-title":"Clin. Microbiol. Infect."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01384-12","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01384-12","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T22:31:49Z","timestamp":1645482709000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01384-12"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["10.1128\/AAC.01384-12"],"URL":"https:\/\/doi.org\/10.1128\/aac.01384-12","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"2012-07-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2012-10-13","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2013-12-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}