{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:58:18Z","timestamp":1791921498741,"version":"4.3.4"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T00:00:00Z","timestamp":1767744000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Elion Therapeutics","award":["22775"],"award-info":[{"award-number":["22775"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,1,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Invasive pulmonary aspergillosis (IPA), mainly caused by\n                      <jats:italic toggle=\"yes\">A. fumigatus,<\/jats:italic>\n                      remains a life-threatening fungal infection, with rising reports of infections caused by resistant species such as\n                      <jats:italic toggle=\"yes\">Aspergillus lentulus<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">Aspergillus calidoustus<\/jats:italic>\n                      . EL219 (formerly known as SF001) is a novel, next-generation polyene with enhanced ergosterol selectivity and reduced nephrotoxicity. We evaluated the efficacy of EL219 compared to liposomal amphotericin B (LAMB)\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      using the Clinical Laboratory and Standards Institute M38 methodology and in immunosuppressed murine models of IPA caused by\n                      <jats:italic toggle=\"yes\">A. fumigatus<\/jats:italic>\n                      ,\n                      <jats:italic toggle=\"yes\">A. lentulus<\/jats:italic>\n                      , and\n                      <jats:italic toggle=\"yes\">A. calidoustus<\/jats:italic>\n                      . Immunosuppressed ICR mice were infected via inhalation (\n                      <jats:italic toggle=\"yes\">A. fumigatus<\/jats:italic>\n                      ) or via intratracheal instillation (\n                      <jats:italic toggle=\"yes\">A. lentulus<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">A. calidoustus<\/jats:italic>\n                      ), then treated intravenously once daily with placebo, EL219 (0.3, 1.5, 7.5, and 30 mg\/kg), or LAMB (5 mg\/kg) starting 16 h post-infection. Treatment lasted 4 days (\n                      <jats:italic toggle=\"yes\">A. fumigatus<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">A. lentulus<\/jats:italic>\n                      ) or 7 days (\n                      <jats:italic toggle=\"yes\">A. calidoustus<\/jats:italic>\n                      ). Survival through Day 21 and lung fungal burden at Day 4 were assessed. EL219 showed enhanced\n                      <jats:italic toggle=\"yes\">in vitro<\/jats:italic>\n                      activity against\n                      <jats:italic toggle=\"yes\">A. lentulus<\/jats:italic>\n                      and\n                      <jats:italic toggle=\"yes\">A. calidoustus<\/jats:italic>\n                      compared to LAMB. EL219 significantly improved survival in a dose-dependent manner, with 30 mg\/kg outperforming LAMB. EL219 also resulted in &gt;5-log fungal burden reductions in\n                      <jats:italic toggle=\"yes\">A. fumigatus<\/jats:italic>\n                      -infected lungs. EL219 demonstrated broad-spectrum efficacy, improved survival, and reduced lung fungal burden, supporting its potential as a novel therapy for IPA.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01400-25","type":"journal-article","created":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T11:03:44Z","timestamp":1764932624000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy assessments of EL219, a next-generation polyene antifungal, in immunosuppressed mice infected with drug-sensitive and drug-resistant\n                    <i>Aspergillus<\/i>\n                    isolates"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3167-1347","authenticated-orcid":false,"given":"Eman G.","family":"Youssef","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/016gb9e15","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Anegeles (UCLA) Medical Center","place":["Torrance, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-6620-6401","authenticated-orcid":false,"given":"Teclegiorgis","family":"Gebremariam","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/016gb9e15","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Anegeles (UCLA) Medical Center","place":["Torrance, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8295-7222","authenticated-orcid":false,"given":"Yiyou","family":"Gu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/016gb9e15","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Anegeles (UCLA) Medical Center","place":["Torrance, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hoja","family":"Patterson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02f6dcw23","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Texas Health Science Center at San Antonio","place":["San Antonio, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sondus","family":"Alkhazraji","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/016gb9e15","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Anegeles (UCLA) Medical Center","place":["Torrance, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasneem","family":"Elsayed","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/016gb9e15","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Anegeles (UCLA) Medical Center","place":["Torrance, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2225-5122","authenticated-orcid":true,"given":"Nathan P.","family":"Wiederhold","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/02f6dcw23","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Texas Health Science Center at San Antonio","place":["San Antonio, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3787-8530","authenticated-orcid":true,"given":"Ashraf S.","family":"Ibrahim","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/016gb9e15","id-type":"ROR","asserted-by":"publisher"}],"name":"Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California Los Anegeles (UCLA) Medical Center","place":["Torrance, USA"]},{"name":"David Geffen School of Medicine at UCLA","place":["Los Angeles, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_5_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/339202"},{"key":"e_1_3_5_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-002-0699-z"},{"key":"e_1_3_5_4_2","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0114-2022"},{"key":"e_1_3_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/apm.13316"},{"key":"e_1_3_5_6_2","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00583-2015"},{"key":"e_1_3_5_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00055-08"},{"key":"e_1_3_5_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-023-00461-5"},{"key":"e_1_3_5_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.70051"},{"key":"e_1_3_5_10_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.00683"},{"key":"e_1_3_5_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00608-17"},{"key":"e_1_3_5_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12281-023-00459-z"},{"key":"e_1_3_5_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2024.1504826"},{"key":"e_1_3_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-023-00727-z"},{"key":"e_1_3_5_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2002.tb04767.x"},{"key":"e_1_3_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0538-7"},{"key":"e_1_3_5_17_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2015.0460"},{"key":"e_1_3_5_18_2","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00001011"},{"key":"e_1_3_5_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-013-1867-1"},{"key":"e_1_3_5_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06710-4"},{"key":"e_1_3_5_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00322-25"},{"key":"e_1_3_5_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01802-24"},{"key":"e_1_3_5_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01631-23"},{"key":"e_1_3_5_24_2","volume-title":"Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi M38-A2","author":"Institute. CLS","year":"2008","unstructured":"Institute. CLS. 2008. Reference Method for Broth Dilution Antifungal Susceptibility Testing of Filamentous Fungi M38-A2. CLSI, PA, USA."},{"key":"e_1_3_5_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.5.1908-1911.2004"},{"key":"e_1_3_5_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.12.3474-3481.2001"},{"key":"e_1_3_5_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/imj.15591"},{"key":"e_1_3_5_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"e_1_3_5_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00313-13"},{"key":"e_1_3_5_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00178-20:AAC.00178-20"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01400-25","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01400-25","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T14:01:12Z","timestamp":1767794472000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.01400-25"}},"subtitle":[],"editor":[{"given":"Damian J.","family":"Krysan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,1,7]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1,7]]}},"alternative-id":["10.1128\/aac.01400-25"],"URL":"https:\/\/doi.org\/10.1128\/aac.01400-25","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,7]]},"assertion":[{"value":"2025-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01400-25"}}