{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T18:16:28Z","timestamp":1783188988087,"version":"3.54.6"},"reference-count":20,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The\n            <jats:italic>in vitro<\/jats:italic>\n            activity of ceftolozane in combination with tazobactam (fixed concentration of 4 \u03bcg\/ml) was evaluated against 2,435\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Pseudomonas aeruginosa<\/jats:named-content>\n            clinical isolates obtained from across Canada using Clinical and Laboratory Standards Institute broth microdilution methods. The MIC\n            <jats:sub>50<\/jats:sub>\n            and MIC\n            <jats:sub>90<\/jats:sub>\n            values for ceftolozane-tazobactam were 0.5 \u03bcg\/ml and 1 \u03bcg\/ml, respectively (a 32-fold-lower MIC\n            <jats:sub>90<\/jats:sub>\n            than that for ceftazidime). Eighty-nine percent (141\/158) of multidrug-resistant isolates were inhibited by \u22648 \u03bcg\/ml of ceftolozane-tazobactam.\n          <\/jats:p>","DOI":"10.1128\/aac.01404-13","type":"journal-article","created":{"date-parts":[[2013,8,13]],"date-time":"2013-08-13T03:35:50Z","timestamp":1376364950000},"page":"5707-5709","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":32,"title":["<i>In Vitro<\/i>\n            Activity of Ceftolozane-Tazobactam against Pseudomonas aeruginosa Isolates Obtained from Patients in Canadian Hospitals in the CANWARD Study, 2007 to 2012"],"prefix":"10.1128","volume":"57","author":[{"given":"A.","family":"Walkty","sequence":"first","affiliation":[{"name":"Departments of Medicine and Clinical Microbiology, Health Sciences Centre, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Department of Clinical Microbiology, Diagnostic Services Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. A.","family":"Karlowsky","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Diagnostic Services Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Adam","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Diagnostic Services Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Baxter","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Lagac\u00e9-Wiens","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Diagnostic Services Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. J.","family":"Hoban","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Diagnostic Services Manitoba, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. G.","family":"Zhanel","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Clinical Microbiology, Health Sciences Centre, University of Manitoba, Winnipeg, Manitoba, Canada"},{"name":"Department of Medical Microbiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00469-10"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/432803"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2004.05.003"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(01)00254-1"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.05.007"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00338-07"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268810003055"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00207-10"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.1.43-48.2006"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/595011"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00912-09"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00834-09"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01104-09"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/338782"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.05.019"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00296-10"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00860-06"},{"key":"e_1_3_2_19_2","volume-title":"Performance standards for antimicrobial susceptibility testing: 22nd informational supplement M100-S22","author":"Clinical and Laboratory Standards Institute","year":"2012","unstructured":"Clinical and Laboratory Standards Institute. 2012. Performance standards for antimicrobial susceptibility testing: 22nd informational supplement M100-S22. CLSI, Wayne, PA."},{"key":"e_1_3_2_20_2","volume-title":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically","author":"Clinical and Laboratory Standards Institute","year":"2006","unstructured":"Clinical and Laboratory Standards Institute. 2006. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically, 7th ed. Approved standard M7-A7. 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