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These have poor activity against the blood-stage plasmodia causing acute malaria and must be used in conjunction with partner blood schizontocidal agents. We examined the impacts of one such agent, chloroquine, upon the activity of primaquine, an 8-aminoquinoline, against hepatic stages of\n            <jats:named-content content-type=\"genus-species\">Plasmodium cynomolgi<\/jats:named-content>\n            ,\n            <jats:named-content content-type=\"genus-species\">Plasmodium yoelii<\/jats:named-content>\n            ,\n            <jats:named-content content-type=\"genus-species\">Plasmodium berghei<\/jats:named-content>\n            , and\n            <jats:named-content content-type=\"genus-species\">Plasmodium falciparum<\/jats:named-content>\n            within several\n            <jats:italic>ex vivo<\/jats:italic>\n            systems\u2014primary hepatocytes of\n            <jats:named-content content-type=\"genus-species\">Macaca fascicularis<\/jats:named-content>\n            , primary human hepatocytes, and stably transformed human hepatocarcinoma cell line HepG2.\n          <\/jats:p>","DOI":"10.1128\/aac.01416-20","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T15:00:14Z","timestamp":1603119614000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":8,"title":["Chloroquine Potentiates Primaquine Activity against Active and Latent Hepatic Plasmodia\n            <i>Ex Vivo<\/i>\n            : Potentials and Pitfalls"],"prefix":"10.1128","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9087-8439","authenticated-orcid":false,"given":"Laurent","family":"Demb\u00e9l\u00e9","sequence":"first","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, CNRS, INSERM U1135, Centre d\u2019Immunologie et des Maladies Infectieuses, CIMI-Paris, Paris, France"},{"name":"Universit\u00e9 des Sciences, des Techniques et des Technologies de Bamako (USTTB), Bamako, Mali"},{"name":"Malaria Research and Training Centre (MRTC), Faculty of Pharmacy, Bamako, Mali"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Fran\u00e7ois","family":"Franetich","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, CNRS, INSERM U1135, Centre d\u2019Immunologie et des Maladies Infectieuses, CIMI-Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Soulard","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, CNRS, INSERM U1135, Centre d\u2019Immunologie et des Maladies Infectieuses, CIMI-Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Amanzougaghene","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, CNRS, INSERM U1135, Centre d\u2019Immunologie et des Maladies Infectieuses, CIMI-Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahin","family":"Tajeri","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, INSERM, CNRS, INSERM U1135, Centre d\u2019Immunologie et des Maladies Infectieuses, CIMI-Paris, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2666-094X","authenticated-orcid":false,"given":"Teun","family":"Bousema","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geert-Jan","family":"van Gemert","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Le Grand","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-Immune, Hematalogical and Bacterial Diseases (IMVA-HB\/IDMIT), Fontenay-aux-Roses, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Dereuddre-Bosquet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, Inserm, CEA, Center for Immunology of Viral, Auto-Immune, Hematalogical and Bacterial Diseases (IMVA-HB\/IDMIT), Fontenay-aux-Roses, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2170-300X","authenticated-orcid":false,"given":"J. 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