{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:04:21Z","timestamp":1791266661998,"version":"4.1.0"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The present article is a study of the in vitro susceptibility of eight Greek\n            <jats:italic>Coxiella burnetii<\/jats:italic>\n            isolates, derived from patients with acute Q fever, and two reference strains of\n            <jats:italic>Coxiella burnetii<\/jats:italic>\n            to tigecycline. The bacteriostatic activity of tigecycline was compared with those of six other antibiotics using a shell vial assay. The MICs of the examined antibiotics were as follows: tigecycline ranged from 0.25 to 0.5 \u03bcg\/ml; doxycycline, trovafloxacin, and ofloxacin ranged from 1 to 2 \u03bcg\/ml; linezolid and clarithromycin ranged from 2 to 4 \u03bcg\/ml; and ciprofloxacin ranged from 4 to 8 \u03bcg\/ml. Tigecycline was effective in inhibiting the infection of Vero cells by\n            <jats:italic>C. burnetii<\/jats:italic>\n            . No bactericidal activity was observed against\n            <jats:italic>C. burnetii<\/jats:italic>\n            at 4 \u03bcg\/ml.\n          <\/jats:p>","DOI":"10.1128\/aac.01424-08","type":"journal-article","created":{"date-parts":[[2009,3,31]],"date-time":"2009-03-31T01:43:10Z","timestamp":1238463790000},"page":"2690-2692","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":25,"title":["Bacteriostatic and Bactericidal Activities of Tigecycline against\n            <i>Coxiella burnetii<\/i>\n            and Comparison with Those of Six Other Antibiotics"],"prefix":"10.1128","volume":"53","author":[{"given":"Ioanna","family":"Spyridaki","sequence":"first","affiliation":[{"name":"Department of Bacteriology, Parasitology, Zoonoses and Geographical Medicine, Faculty of Medicine, University of Crete, P.O. Box 1393, Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Psaroulaki","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Parasitology, Zoonoses and Geographical Medicine, Faculty of Medicine, University of Crete, P.O. Box 1393, Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iosif","family":"Vranakis","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Parasitology, Zoonoses and Geographical Medicine, Faculty of Medicine, University of Crete, P.O. Box 1393, Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannis","family":"Tselentis","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Parasitology, Zoonoses and Geographical Medicine, Faculty of Medicine, University of Crete, P.O. Box 1393, Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achilleas","family":"Gikas","sequence":"additional","affiliation":[{"name":"Department of Bacteriology, Parasitology, Zoonoses and Geographical Medicine, Faculty of Medicine, University of Crete, P.O. Box 1393, Heraklion, Crete, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1348-0421.2004.tb03476.x","volume":"48","year":"2004","unstructured":"Andoh, M., N. Takashi, Y. Tsuyoshi, F. Hideto, and H. Katsuya. 2004. In vitro susceptibility to tetracycline and fluoroquinolones of Japanese isolates of Coxiella burnetii. Microbiol. Immunol.48:661-664.","journal-title":"Microbiol. 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Correlation between serum doxycycline concentrations and serologic evolution in patients with Coxiella burnetii endocarditis. J. Infect. Dis.188:1322-1325.","journal-title":"J. Infect. Dis."},{"key":"e_1_3_1_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.7.2673-2676.2005"},{"key":"e_1_3_1_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.36.7.2063-2067.1998"},{"key":"e_1_3_1_21_2","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1093\/clinids\/20.5.1311","volume":"20","year":"1995","unstructured":"Tselentis, Y., A. Gikas, D. Kofteridis, E. Kyriakakis, N. Lydataki, D. Bouros, and N. Tsaparas. 1995. Q fever in the Greek island of Crete: epidemiological, clinical, and therapeutic data from 98 cases. Clin. Infect. Dis.20:1311-1316.","journal-title":"Clin. Infect. 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