{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:18:18Z","timestamp":1787239098831,"version":"build-2736575974"},"reference-count":70,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["666-2014"],"award-info":[{"award-number":["666-2014"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19AI129910"],"award-info":[{"award-number":["U19AI129910"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI103036"],"award-info":[{"award-number":["AI103036"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["SD43TW006589"],"award-info":[{"award-number":["SD43TW006589"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2022,1,18]]},"abstract":"<jats:p>Failure of treatment of cutaneous leishmaniasis with antimonial drugs and miltefosine is frequent. Use of oral combination therapy represents an attractive strategy to increase efficacy of treatment and reduce the risk of drug resistance.<\/jats:p>","DOI":"10.1128\/aac.01425-21","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T14:50:23Z","timestamp":1635173423000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":10,"title":["Potency and Preclinical Evidence of Synergy of Oral Azole Drugs and Miltefosine in an\n                    <i>Ex Vivo<\/i>\n                    Model of\n                    <i>Leishmania<\/i>\n                    (\n                    <i>Viannia<\/i>\n                    )\n                    <i>panamensis<\/i>\n                    Infection"],"prefix":"10.1128","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1624-0191","authenticated-orcid":true,"given":"Olga Luc\u00eda","family":"Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"Centro Internacional de Entrenamiento e Investigaciones M\u00e9dicas (CIDEIM), Cali, Colombia"},{"name":"Universidad Icesi, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Rosales-Chilama","sequence":"additional","affiliation":[{"name":"Centro Internacional de Entrenamiento e Investigaciones M\u00e9dicas (CIDEIM), Cali, Colombia"},{"name":"Universidad Icesi, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natali","family":"Quintero","sequence":"additional","affiliation":[{"name":"Centro Internacional de Entrenamiento e Investigaciones M\u00e9dicas (CIDEIM), Cali, Colombia"},{"name":"Universidad Icesi, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno L.","family":"Travi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, University of Texas Medical Branch (UTMB), Galveston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn M.","family":"Wetzel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA"},{"name":"Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Adelaida","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Centro Internacional de Entrenamiento e Investigaciones M\u00e9dicas (CIDEIM), Cali, Colombia"},{"name":"Universidad Icesi, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy Gore","family":"Saravia","sequence":"additional","affiliation":[{"name":"Centro Internacional de Entrenamiento e Investigaciones M\u00e9dicas (CIDEIM), Cali, Colombia"},{"name":"Universidad Icesi, Cali, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/383321"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/524042"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.72.421"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jir816"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2010.10-0060"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002871"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/510860"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02198-16"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2012.12.006"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2008.78.210"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1086\/322689"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2011.10-0155"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0001-706X(01)00197-8"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2005.73.272"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01023-13"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00216-12"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.drup.2006.04.001"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.04.014"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(96)00128-2"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(90)90292-L"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186117"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1470-9465.2004.00841.x"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1368-5031.2004.00167.x"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(05)70297-8"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2006.01295.x"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003588"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0166-6851(88)90166-1"},{"key":"e_1_3_2_29_2","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.4269\/ajtmh.16-0373","article-title":"In vitro sensitivity of cutaneous Leishmania promastigote isolates circulating in French Guiana to a set of drugs","volume":"96","author":"Ginouv\u00e8s M","year":"2017","unstructured":"Ginouv\u00e8s M, Simon S, Nacher M, Demar M, Carme B, Couppi\u00e9 P, Pr\u00e9vot G. 2017. In vitro sensitivity of cutaneous Leishmania promastigote isolates circulating in French Guiana to a set of drugs. Am J Trop Med Hyg 96:1143\u20131150.","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-013-3274-x"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083247"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2002.66.738"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.7705\/biomedica.v26i1.1508"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.106084"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.5.1561-1564.2001"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03190361"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1086\/648679"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-12-263"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02465-17"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/396894"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00198314"},{"key":"e_1_3_2_42_2","first-page":"1","article-title":"Pharmacokinetics and safety of posaconazole delayed-release tablets for invasive fungal infections","volume":"8","author":"Wiederhold NP","year":"2016","unstructured":"Wiederhold NP. 2016. Pharmacokinetics and safety of posaconazole delayed-release tablets for invasive fungal infections. Clin Pharmacol 8:1\u20138.","journal-title":"Clin Pharmacol"},{"key":"e_1_3_2_43_2","first-page":"1530","article-title":"Pharmacokinetics, safety, and efficacy of an allometric miltefosine regimen for the treatment of visceral leishmaniasis in eastern African children: an open-label, phase II clinical trial","volume":"68","author":"Mbui J","year":"2019","unstructured":"Mbui J, Olobo J, Omollo R, Solomos A, Kip AE, Kirigi G, Sagaki P, Kimutai R, Were L, Omollo T, Egondi TW, Wasunna M, Alvar J, Dorlo TPC, Alves F. 2019. Pharmacokinetics, safety, and efficacy of an allometric miltefosine regimen for the treatment of visceral leishmaniasis in eastern African children: an open-label, phase II clinical trial. Clin Infect Dis 68:1530\u20131538.","journal-title":"Clin Infect Dis"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01407-09"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2002.tb04770.x"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01498-10"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1470.2006.00177.x"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2014.04.003"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1155\/2009\/642502"},{"key":"e_1_3_2_50_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006297"},{"key":"e_1_3_2_51_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00163-06"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00046-13"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01616-09"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/12.supplement_3.s318"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70037-7"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.31.1.6"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.4.903"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-013-1998-2"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.5863\/1551-6776-25.1.47"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04035-14"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1592\/phco.28.5.614"},{"key":"e_1_3_2_62_2","volume-title":"Red book: 2018\u20132021 report of the committee on infectious diseases","author":"Brady MT","year":"2018","unstructured":"Brady MT, Kimberlin DW, Long SS (ed). 2018. Red book: 2018\u20132021 report of the committee on infectious diseases, 31st ed. American Academy of Pediatrics, Itasca, IL.","edition":"31"},{"key":"e_1_3_2_63_2","doi-asserted-by":"publisher","DOI":"10.7705\/biomedica.v39i3.4312"},{"key":"e_1_3_2_64_2","doi-asserted-by":"publisher","DOI":"10.1645\/GE-3489.1"},{"key":"e_1_3_2_65_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0003820"},{"key":"e_1_3_2_66_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01075-08"},{"key":"e_1_3_2_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2014.04.005"},{"key":"e_1_3_2_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molbiopara.2012.03.002"},{"key":"e_1_3_2_69_2","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1996.0383"},{"key":"e_1_3_2_70_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000819"},{"key":"e_1_3_2_71_2","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.200410124"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01425-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01425-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T15:46:11Z","timestamp":1725983171000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01425-21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,18]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1,18]]}},"alternative-id":["10.1128\/AAC.01425-21"],"URL":"https:\/\/doi.org\/10.1128\/aac.01425-21","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,18]]},"assertion":[{"value":"2021-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01425-21"}}