{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:57:35Z","timestamp":1761490655768,"version":"3.41.2"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T00:00:00Z","timestamp":1543190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T00:00:00Z","timestamp":1543622400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:p>\n            Mutations in the kelch propeller domain (K13 propeller) of\n            <jats:named-content content-type=\"genus-species\">Plasmodium falciparum<\/jats:named-content>\n            parasites from Southeast Asia are associated with reduced susceptibility to artemisinin. We exposed\n            <jats:italic>in vitro<\/jats:italic>\n            -cultured stage V gametocytes from Cambodian K13 propeller mutant parasites to dihydroartemisinin and evaluated the inhibition of male gamete formation in an\n            <jats:italic>in vitro<\/jats:italic>\n            exflagellation inhibition assay (EIA).\n          <\/jats:p>","DOI":"10.1128\/aac.01426-18","type":"journal-article","created":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T14:08:11Z","timestamp":1537193291000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":14,"title":["Gametocytes from K13 Propeller Mutant Plasmodium falciparum Clinical Isolates Demonstrate Reduced Susceptibility to Dihydroartemisinin in the Male Gamete Exflagellation Inhibition Assay"],"prefix":"10.1128","volume":"62","author":[{"given":"Sonia","family":"Lozano","sequence":"first","affiliation":[{"name":"Diseases of the Developing World (DDW), Global Health R&amp;D, GlaxoSmithKline, Tres Cantos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Gamallo","sequence":"additional","affiliation":[{"name":"Diseases of the Developing World (DDW), Global Health R&amp;D, GlaxoSmithKline, Tres Cantos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Gonz\u00e1lez-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Diseases of the Developing World (DDW), Global Health R&amp;D, GlaxoSmithKline, Tres Cantos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas-Lu\u00eds","family":"Presa Matilla","sequence":"additional","affiliation":[{"name":"Diseases of the Developing World (DDW), Global Health R&amp;D, GlaxoSmithKline, Tres Cantos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick M.","family":"Fairhurst","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esperanza","family":"Herreros","sequence":"additional","affiliation":[{"name":"Diseases of the Developing World (DDW), Global Health R&amp;D, GlaxoSmithKline, Tres Cantos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanaki","family":"Amaratunga","sequence":"additional","affiliation":[{"name":"Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janneth","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Diseases of the Developing World (DDW), Global Health R&amp;D, GlaxoSmithKline, Tres Cantos, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","volume-title":"Guidelines for the treatment of malaria","author":"WHO","year":"2015","unstructured":"WHO. 2015. 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