{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T20:57:38Z","timestamp":1768769858987,"version":"3.49.0"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2009,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Preterm premature rupture of the membranes is associated with a high risk of neonatal sepsis. An increase in the incidence of early-onset neonatal sepsis due to ampicillin-resistant\n            <jats:italic>Escherichia coli<\/jats:italic>\n            in premature infants has been observed in the past few years. Intrapartum prophylaxis with ampicillin has proven to be efficient for the prevention of early neonatal sepsis due to group B streptococci. To date, there is no strategy for the prevention of early neonatal sepsis due to ampicillin-resistant\n            <jats:italic>E. coli<\/jats:italic>\n            . Our aim was to investigate whether a standardized dosage regimen of intrapartum cefotaxime could provide concentrations in the cord blood greater than the cefotaxime MIC\n            <jats:sub>90<\/jats:sub>\n            for\n            <jats:italic>E. coli<\/jats:italic>\n            . Seven pregnant women hospitalized with preterm premature rupture of the membranes and colonized with ampicillin-resistant isolates of the family\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            were included. Cefotaxime was given intravenously during delivery, as follows: 2 g at the onset of labor and then 1 g every 4 h until delivery. Blood specimens were collected from the mother 30 min after the first injection and just before the second injection, and at birth, blood specimens were simultaneously collected from the mother and the umbilical cord. The concentrations of cefotaxime in the cord blood ranged from 0.5 to 8.5 mg\/liter. The MIC\n            <jats:sub>90<\/jats:sub>\n            of cefotaxime for\n            <jats:italic>E. coli<\/jats:italic>\n            strains (0.125 mg\/liter) was achieved in all cases. This preliminary study supports the use of cefotaxime for intrapartum prophylaxis in women colonized with ampicillin-resistant isolates of\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            . The effectiveness of this regimen for the prevention of neonatal sepsis needs to be evaluated with a larger population.\n          <\/jats:p>","DOI":"10.1128\/aac.01429-08","type":"journal-article","created":{"date-parts":[[2009,3,24]],"date-time":"2009-03-24T01:39:47Z","timestamp":1237858787000},"page":"2342-2345","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of Cefotaxime and Desacetylcefotaxime Concentrations in Cord Blood after Intrapartum Prophylaxis with Cefotaxime"],"prefix":"10.1128","volume":"53","author":[{"given":"Jacques","family":"Lepercq","sequence":"first","affiliation":[{"name":"Universite\u0301 Paris Descartes, Assistance Publique-Ho\u0302pitaux de Paris"},{"name":"Service de Gyne\u0301cologie Obstetrique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Marc","family":"Treluyer","sequence":"additional","affiliation":[{"name":"Universite\u0301 Paris Descartes, Assistance Publique-Ho\u0302pitaux de Paris"},{"name":"Service de Pharmacologie Clinique"},{"name":"EA 320, Groupe Hospitalier Cochin Saint Vincent de Paul, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christelle","family":"Auger","sequence":"additional","affiliation":[{"name":"Universite\u0301 Paris Descartes, Assistance Publique-Ho\u0302pitaux de Paris"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josette","family":"Raymond","sequence":"additional","affiliation":[{"name":"Universite\u0301 Paris Descartes, Assistance Publique-Ho\u0302pitaux de Paris"},{"name":"Service de Bacte\u0301riologie"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Rey","sequence":"additional","affiliation":[{"name":"Universite\u0301 Paris Descartes, Assistance Publique-Ho\u0302pitaux de Paris"},{"name":"Service de Pharmacologie Clinique"},{"name":"INSERM U663"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Universite\u0301 Paris Descartes, Assistance Publique-Ho\u0302pitaux de Paris"},{"name":"Service de Gyne\u0301cologie Obstetrique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Jullien","sequence":"additional","affiliation":[{"name":"Universite\u0301 Paris Descartes, Assistance Publique-Ho\u0302pitaux de Paris"},{"name":"Service de Pharmacologie Clinique"},{"name":"INSERM U663"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Diagnostic et traitement curatif de l'infection bact\u00e9rienne pr\u00e9coce du nouveau n\u00e9 2003"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1111\/j.1528-1167.2006.00576.x","volume":"47","year":"2006","unstructured":"Allegaert, K., L. Lewi, G. Naulaers, and L. Lagae. 2006. Levetiracetam pharmacokinetics in neonates at birth. Epilepsia47:1068-1069.","journal-title":"Epilepsia"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn362"},{"key":"e_1_3_2_5_2","unstructured":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically 2006"},{"key":"e_1_3_2_6_2","first-page":"991","year":"2002","unstructured":"Craig, W. A. 2002. Pharmacodynamics of antimicrobials: general concepts and applications, p. 991-1022. In C. Nightingale, T. Marakawa, and P. G. Ambrose (ed.), Antimicrobial pharmacodynamics in theory and clinical practice. Marcel Dekker, New York, NY.","journal-title":"Antimicrobial pharmacodynamics in theory and clinical practice"},{"key":"e_1_3_2_7_2","first-page":"255","volume":"81","year":"1993","unstructured":"De Leeuw, J. W., F. J. Roumen, P. X. Bouckaert, H. M. Cremers, and T. B. Vree. 1993. Achievement of therapeutic concentrations of cefuroxime in early preterm gestations with premature rupture of the membranes. Obstet. Gynecol.81:255-260.","journal-title":"Obstet. Gynecol."},{"key":"e_1_3_2_8_2","first-page":"1849","volume":"35","year":"1982","unstructured":"Fujimoto, S., and Y. Kanagawa. 1982. Studies on the transplacental passage of cefotaxime in late pregnancy. Jpn. J. Antibiot.35:1849-1854.","journal-title":"Jpn. J. Antibiot."},{"key":"e_1_3_2_9_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000480936","volume":"14","year":"1990","unstructured":"Gouyon, J. B., A. Pechinot, C. Safran, P. Chretien, D. Sandre, and A. Kazmierczak. 1990. Pharmacokinetics of cefotaxime in preterm infants. Dev. Pharmacol. Ther.14:29-34.","journal-title":"Dev. Pharmacol. Ther."},{"key":"e_1_3_2_10_2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1136\/adc.68.1_Spec_No.54","volume":"68","year":"1993","unstructured":"Holt, D. E., N. M. Fisk, J. A. Spencer, de J. Louvois, R. Hurley, and D. Harvey. 1993. Transplacental transfer of cefuroxime in uncomplicated pregnancies and those complicated by hydrops or changes in amniotic fluid volume. Arch. Dis. Child.68:54-57.","journal-title":"Arch. Dis. Child."},{"key":"e_1_3_2_11_2","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1111\/j.1479-828X.2004.00304.x","volume":"44","year":"2004","unstructured":"Jones, B., K. Peake, A. J. Morris, L. M. McCowan, and M. R. Battin. 2004. Escherichia coli: a growing problem in early onset neonatal sepsis. Aust. N. Z. J. Obstet. Gynaecol.44:558-561.","journal-title":"Aust. N. Z. J. Obstet. Gynaecol."},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0732-8893(95)00043-A"},{"key":"e_1_3_2_13_2","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1097\/01.AOG.0000143268.36682.21","volume":"104","year":"2004","unstructured":"Kenyon, S., M. Boulvain, and J. Neilson. 2004. Antibiotics for preterm rupture of the membranes: a systematic review. Obstet. Gynecol.104(5 Pt 1):1051-1057.","journal-title":"Obstet. Gynecol."},{"key":"e_1_3_2_14_2","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/S0002-9378(99)70307-8","volume":"181","year":"1999","unstructured":"Mercer, B. M., T. L. Carr, D. D. Beazley, D. T. Crouse, and B. M. Sibai. 1999. Antibiotic use in pregnancy and drug-resistant infant sepsis. Am. J. Obstet. Gynecol.181:816-821.","journal-title":"Am. J. Obstet. Gynecol."},{"key":"e_1_3_2_15_2","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0732-8893(95)00074-K","volume":"22","year":"1995","unstructured":"Nix, D. E., and J. J. Schentag. 1995. Role of pharmacokinetics and pharmacodynamics in the design of dosage schedules for 12-h cefotaxime alone and in combination with other antibiotics. Diagn. Microbiol. Infect. Dis.22:71-76.","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"e_1_3_2_16_2","doi-asserted-by":"crossref","first-page":"77S","DOI":"10.1016\/j.diagmicrobio.2006.12.012","volume":"57","year":"2007","unstructured":"Owens, R. C., Jr., and P. G. Ambrose. 2007. Antimicrobial stewardship and the role of pharmacokinetics-pharmacodynamics in the modern antibiotic era. Diagn. Microbiol. Infect. Dis.57(Suppl. 3):77S-83S.","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"e_1_3_2_17_2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1056\/NEJM199803053381006","volume":"338","year":"1998","unstructured":"Parry, S., and J. F. Strauss III. 1998. Premature rupture of the fetal membranes. N. Engl. J. Med.338:663-670.","journal-title":"N. Engl. J. Med."},{"key":"e_1_3_2_18_2","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/INF.0b013e31815b1b03","volume":"27","year":"2008","unstructured":"Raymond, J., E. Lopez, S. Bonacorsi, C. Poyart, G. Moriette, P. H. Jarreau, and E. Bingen. 2008. Evidence for transmission of Escherichia coli from mother to child in late-onset neonatal infection. Pediatr. Infect. Dis. J.27:186-188.","journal-title":"Pediatr. Infect. Dis. J."},{"key":"e_1_3_2_19_2","first-page":"1581","year":"1999","unstructured":"Romero, R., N. Athayde, E. Maymon, P. Pacora, and R. Bahado-Singh. 1999. Premature rupture of the membranes, p. 1581-1625. In A. Reece and J. Hobbins (ed.), Medicine of the fetus and mother. Lippincott-Raven, Philadelphia, PA.","journal-title":"Medicine of the fetus and mother"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001063420103"},{"key":"e_1_3_2_21_2","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1542\/peds.2005-3083","volume":"118","year":"2006","unstructured":"Schrag, S. J., J. L. Hadler, K. E. Arnold, P. Martell-Cleary, A. Reingold, and A. Schuchat. 2006. Risk factors for invasive, early-onset Escherichia coli infections in the era of widespread intrapartum antibiotic use. Pediatrics118:570-576.","journal-title":"Pediatrics"},{"key":"e_1_3_2_22_2","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S0022-3476(96)70192-0","volume":"129","year":"1996","unstructured":"Stoll, B. J., T. Gordon, S. B. Korones, S. Shankaran, J. E. Tyson, C. R. Bauer, A. A. Fanaroff, J. A. Lemons, E. F. Donovan, W. Oh, D. K. Stevenson, R. A. Ehrenkranz, L. A. Papile, J. Verter, and L. L. Wright. 1996. Early-onset sepsis in very low birth weight neonates: a report from the National Institute of Child Health and Human Development Neonatal Research Network. J. Pediatr.129:72-80.","journal-title":"J. Pediatr."},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012657"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200443080-00001"},{"key":"e_1_3_2_25_2","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1016\/S0002-9378(99)70017-7","volume":"180","year":"1999","unstructured":"Terrone, D. A., B. K. Rinehart, M. H. Einstein, L. B. Britt, J. N. Martin, Jr., and K. G. Perry. 1999. Neonatal sepsis and death caused by resistant Escherichia coli: possible consequences of extended maternal ampicillin administration. Am. J. Obstet. Gynecol.180(6 Pt 1):1345-1348.","journal-title":"Am. J. Obstet. Gynecol."},{"key":"e_1_3_2_26_2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1067\/mob.2002.124277","volume":"187","year":"2002","unstructured":"Towers, C. V., and G. G. Briggs. 2002. Antepartum use of antibiotics and early-onset neonatal sepsis: the next 4 years. Am. J. Obstet. Gynecol.187:495-500.","journal-title":"Am. J. Obstet. Gynecol."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01429-08","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01429-08","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T23:17:48Z","timestamp":1645485468000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01429-08"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["10.1128\/AAC.01429-08"],"URL":"https:\/\/doi.org\/10.1128\/aac.01429-08","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,6]]},"assertion":[{"value":"2008-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2009-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}