{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:41:57Z","timestamp":1791229317276,"version":"4.1.0"},"reference-count":23,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2007,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The susceptibility trends for the species of the\n            <jats:italic>Bacteroides fragilis<\/jats:italic>\n            group against various antibiotics from 1997 to 2004 were determined by using data for 5,225 isolates referred by 10 medical centers. The antibiotic test panel included ertapenem, imipenem, meropenem, ampicillin-sulbactam, piperacillin-tazobactam, cefoxitin, clindamycin, moxifloxacin, tigecycline, chloramphenicol, and metronidazole. From 1997 to 2004 there were decreases in the geometric mean (GM) MICs of imipenem, meropenem, piperacillin-tazobactam, and cefoxitin for many of the species within the group.\n            <jats:italic>B. distasonis<\/jats:italic>\n            showed the highest rates of resistance to most of the \u03b2-lactams.\n            <jats:italic>B. fragilis<\/jats:italic>\n            ,\n            <jats:italic>B. ovatus<\/jats:italic>\n            , and\n            <jats:italic>B. thetaiotaomicron<\/jats:italic>\n            showed significantly higher GM MICs and rates of resistance to clindamycin over time. The rate of resistance to moxifloxacin of\n            <jats:italic>B. vulgatus<\/jats:italic>\n            was very high (MIC range for the 8-year study period, 38% to 66%).\n            <jats:italic>B. fragilis<\/jats:italic>\n            ,\n            <jats:italic>B. ovatus<\/jats:italic>\n            , and\n            <jats:italic>B. distasonis<\/jats:italic>\n            and other\n            <jats:italic>Bacteroides<\/jats:italic>\n            spp. exhibited significant increases in the rates of resistance to moxifloxacin over the 8 years. Resistance rates and GM MICs for tigecycline were low and stable during the 5-year period over which this agent was studied. All isolates were susceptible to chloramphenicol (MICs &lt; 16 \u03bcg\/ml). In 2002, one isolate resistant to metronidazole (MIC = 64 \u03bcg\/ml) was noted. These data indicate changes in susceptibility over time; surprisingly, some antimicrobial agents are more active now than they were 5 years ago.\n          <\/jats:p>","DOI":"10.1128\/aac.01435-06","type":"journal-article","created":{"date-parts":[[2007,2,6]],"date-time":"2007-02-06T01:36:47Z","timestamp":1170725807000},"page":"1649-1655","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":147,"title":["National Survey on the Susceptibility of\n            <i>Bacteroides fragilis<\/i>\n            Group: Report and Analysis of Trends in the United States from 1997 to 2004"],"prefix":"10.1128","volume":"51","author":[{"given":"D. R.","family":"Snydman","sequence":"first","affiliation":[{"name":"Departments of Medicine, Community Health and Clinical Research, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. V.","family":"Jacobus","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Community Health and Clinical Research, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A.","family":"McDermott","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Community Health and Clinical Research, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Ruthazer","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Community Health and Clinical Research, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Golan","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Community Health and Clinical Research, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. J. C.","family":"Goldstein","sequence":"additional","affiliation":[{"name":"R. M. Alden Research Laboratories, Santa Monica, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Finegold","sequence":"additional","affiliation":[{"name":"Wadsworth Veterans Administration Hospital, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. J.","family":"Harrell","sequence":"additional","affiliation":[{"name":"Duke University Medical Center, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. W.","family":"Hecht","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center, Maywood, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. G.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Carolinas Medical Center, Charlotte, North Carolina, and Mt. 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L.","family":"Gorbach","sequence":"additional","affiliation":[{"name":"Departments of Medicine, Community Health and Clinical Research, New England Medical Center, Tufts University School of Medicine, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","unstructured":"Categorical data analysis 1990"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.4.1238-1243.2001"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.11.4349-4352.2002"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dki197"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2005.06.012"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/44.4.580"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg320"},{"key":"e_1_3_2_9_2","unstructured":"Abstr. 41st Intersci. Conf. Antimicrob. 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