{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T08:33:53Z","timestamp":1776501233356,"version":"3.51.2"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We report the penetration of liposomal amphotericin B into the pleural fluid of a patient with pulmonary zygomycosis and empyema. The ratio of area under the concentration-versus-time curve in pleural fluid (AUC\n            <jats:sub>pleural fluid<\/jats:sub>\n            ) to that in serum (AUC\n            <jats:sub>serum<\/jats:sub>\n            ) for liposomal amphotericin B over 24 h was 9.4%, with pleural fluid concentrations of 2.12 to 4.91 \u03bcg\/ml. Given the relatively low level of intrapleural penetration of liposomal amphotericin B, chest tube drainage may be warranted for successful treatment of zygomycotic empyema.\n          <\/jats:p>","DOI":"10.1128\/aac.01438-09","type":"journal-article","created":{"date-parts":[[2010,1,20]],"date-time":"2010-01-20T04:53:18Z","timestamp":1263963198000},"page":"1633-1635","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Pharmacokinetics of Liposomal Amphotericin B in Pleural Fluid"],"prefix":"10.1128","volume":"54","author":[{"given":"Brad","family":"Moriyama","sequence":"first","affiliation":[{"name":"NIH Clinical Center Pharmacy Department, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parizad","family":"Torabi-Parizi","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Department, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra K.","family":"Pratt","sequence":"additional","affiliation":[{"name":"Critical Care Medicine Department, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stacey A.","family":"Henning","sequence":"additional","affiliation":[{"name":"NIH Clinical Center Pharmacy Department, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gennethel","family":"Pennick","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center, San Antonio, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yvonne R.","family":"Shea","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sinchita","family":"Roy Chowdhuri","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"University of Texas Health Science Center, San Antonio, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. John","family":"Barrett","sequence":"additional","affiliation":[{"name":"National Heart Lung and Blood Institute, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas J.","family":"Walsh","sequence":"additional","affiliation":[{"name":"National Cancer Institute, Bethesda, Maryland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/120.4.427"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600780409"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/430710"},{"key":"e_1_3_2_5_2","first-page":"986","volume":"91","year":"2006","unstructured":"Chamilos, G., M. Luna, R. E. Lewis, G. P. Bodey, R. Chemaly, J. J. Tarrand, A. Safdar, I. I. Raad, and D. P. Kontoyiannis. 2006. 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