{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:17:18Z","timestamp":1753881438096,"version":"3.41.2"},"reference-count":10,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100012399","name":"Biomedical Advanced Research and Development Authority","doi-asserted-by":"crossref","award":["HHSO100201400002C"],"award-info":[{"award-number":["HHSO100201400002C"]}],"id":[{"id":"10.13039\/100012399","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015237","name":"The Medicines Company","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015237","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The recently approved combination of meropenem and vaborbactam (Vabomere) is highly active against Gram-negative pathogens, especially\n            <jats:named-content content-type=\"genus-species\">Klebsiella pneumoniae<\/jats:named-content>\n            carbapenemase (KPC)-producing, carbapenem-resistant\n            <jats:named-content content-type=\"genus-species\">Enterobacteriaceae<\/jats:named-content>\n            . We evaluated the efficacy of meropenem-vaborbactam against three clinically relevant isolates in a murine pyelonephritis model. The data indicate that the combination of meropenem and vaborbactam significantly increased bacterial killing compared to that with the untreated controls. These data suggest that this combination may have utility in the treatment of complicated urinary tract infections due to KPC-producing, carbapenem-resistant\n            <jats:named-content content-type=\"genus-species\">Enterobacteriaceae<\/jats:named-content>\n            .\n          <\/jats:p>","DOI":"10.1128\/aac.01439-17","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T00:55:24Z","timestamp":1508201724000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Activity of Meropenem-Vaborbactam against Carbapenem-Resistant Enterobacteriaceae in a Murine Model of Pyelonephritis"],"prefix":"10.1128","volume":"62","author":[{"given":"William J.","family":"Weiss","sequence":"first","affiliation":[{"name":"Pre-Clinical Services at UNT Health Science Center, Fort Worth, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark E.","family":"Pulse","sequence":"additional","affiliation":[{"name":"Pre-Clinical Services at UNT Health Science Center, Fort Worth, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phung","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Pre-Clinical Services at UNT Health Science Center, Fort Worth, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly","family":"Peterson","sequence":"additional","affiliation":[{"name":"Pre-Clinical Services at UNT Health Science Center, Fort Worth, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Silva","sequence":"additional","affiliation":[{"name":"Pre-Clinical Services at UNT Health Science Center, Fort Worth, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerry W.","family":"Simecka","sequence":"additional","affiliation":[{"name":"Pre-Clinical Services at UNT Health Science Center, Fort Worth, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Valtierra","sequence":"additional","affiliation":[{"name":"Pre-Clinical Services at UNT Health Science Center, Fort Worth, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5417-0262","authenticated-orcid":false,"given":"Mojgan","family":"Sabet","sequence":"additional","affiliation":[{"name":"The Medicines Company, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David C.","family":"Griffith","sequence":"additional","affiliation":[{"name":"The Medicines Company, San Diego, California, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70190-7"},{"key":"e_1_3_2_3_2","unstructured":"U.S. Department of Health and Human Services Centers for Disease Control and Prevention. 2013. Antibiotic resistance threats in the United States 2013. Centers for Disease Control and Prevention Atlanta GA. https:\/\/www.cdc.gov\/drugresistance\/threat-report-2013\/index.html."},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5b00127"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00711-16"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00843-15"},{"key":"e_1_3_2_7_2","volume-title":"Abstr 54th Intersci Conf Antimicrob Agents Chemother","author":"Sabet M","year":"2014","unstructured":"Sabet M, Tarazi Z, Nolan T, Parkinson J, Rubio-Aparicio D, Lomovskaya O, Dudley MN, Griffith DC. 2014. In vivo efficacy of Carbavance (meropenem\/RPX7009) against KPC-producing Enterobacteriaceae, abstr F-959. Abstr 54th Intersci Conf Antimicrob Agents Chemother, American Society of Microbiology, 5 to 9 September 2014, Washington, DC."},{"key":"e_1_3_2_8_2","volume-title":"Performance standards for antimicrobial susceptibility testing","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2015","unstructured":"Clinical and Laboratory Standards Institute (CLSI). 2015. Performance standards for antimicrobial susceptibility testing, 25th ed. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"25"},{"key":"e_1_3_2_9_2","volume-title":"Guide for the care and use of laboratory animals","author":"Institute of Laboratory Animal Resources Commission on Life Sciences, National Research Council","year":"1996","unstructured":"Institute of Laboratory Animal Resources Commission on Life Sciences, National Research Council. 1996. Guide for the care and use of laboratory animals. National Academy Press, Washington, DC."},{"key":"e_1_3_2_10_2","volume-title":"Pharmacodynamics of vaborbactam when administered in combination with meropenem","author":"Griffith DC","year":"2017","unstructured":"Griffith DC, Sabet M, Tarazi Z, Lomovskaya O, Dudley MN. 2017. Pharmacodynamics of vaborbactam when administered in combination with meropenem, abstr Sunday 194, ASM Microbe 2017. American Society of Microbiology, 1 to 5 June 2017, New Orleans, LA."},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01329-17"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01439-17","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01439-17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T21:12:43Z","timestamp":1645477963000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01439-17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":10,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1128\/AAC.01439-17"],"URL":"https:\/\/doi.org\/10.1128\/aac.01439-17","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"type":"print","value":"0066-4804"},{"type":"electronic","value":"1098-6596"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"2017-07-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01439-17"}}