{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T13:48:00Z","timestamp":1790171280879,"version":"4.1.0"},"reference-count":43,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,2,21]]},"abstract":"<jats:p>\n            High rates of artemisinin-based combination therapy (ACT) failures in the treatment of\n            <jats:named-content content-type=\"genus-species\">Plasmodium falciparum<\/jats:named-content>\n            malaria in Southeast Asia have led to triple-drug strategies to extend the useful life of ACTs. In this study, we determined whether methylene blue [MB; 3,7-bis(dimethylamino)phenothiazin-5-ium chloride hydrate] alters the pharmacokinetics of artesunate-amodiaquine (ASAQ) and enhances the\n            <jats:italic>ex vivo<\/jats:italic>\n            antimalarial activity of ASAQ.\n          <\/jats:p>","DOI":"10.1128\/aac.01441-19","type":"journal-article","created":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T12:20:45Z","timestamp":1578313245000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":16,"title":["Pharmacokinetics and\n            <i>Ex Vivo<\/i>\n            Antimalarial Activity of Artesunate-Amodiaquine plus Methylene Blue in Healthy Volunteers"],"prefix":"10.1128","volume":"64","author":[{"given":"Chu Xuan","family":"Anh","sequence":"first","affiliation":[{"name":"Institute for Clinical Infectious Diseases, Central Military Hospital 108, Hanoi, Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Chavchich","sequence":"additional","affiliation":[{"name":"Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey W.","family":"Birrell","sequence":"additional","affiliation":[{"name":"Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Van Breda","sequence":"additional","affiliation":[{"name":"Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Travers","sequence":"additional","affiliation":[{"name":"Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerryn","family":"Rowcliffe","sequence":"additional","affiliation":[{"name":"Australian Defence Force Malaria and Infectious Disease Institute, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton R.","family":"Lord","sequence":"additional","affiliation":[{"name":"Queensland Institute of Medical Research Berghofer, Brisbane, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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