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The drug was well tolerated and safe and reduced both the incidence of tuberculosis coinfection by 42.2% (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05) and the cumulative incidence of opportunistic infections (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.05). These results warrant further clinical investigation of HE2000.\n          <\/jats:p>","DOI":"10.1128\/aac.01446-06","type":"journal-article","created":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T01:05:03Z","timestamp":1177981503000},"page":"2639-2641","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":24,"title":["Safety and Activity of the Immune Modulator HE2000 on the Incidence of Tuberculosis and Other Opportunistic Infections in AIDS Patients"],"prefix":"10.1128","volume":"51","author":[{"given":"Dwight R.","family":"Stickney","sequence":"first","affiliation":[{"name":"Hollis-Eden Pharmaceuticals, Inc., San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoja","family":"Noveljic","sequence":"additional","affiliation":[{"name":"Karl Bremmer Hospital, Cape Town, Republic of South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Garsd","sequence":"additional","affiliation":[{"name":"Hollis-Eden Pharmaceuticals, Inc., San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Destiche","sequence":"additional","affiliation":[{"name":"Hollis-Eden Pharmaceuticals, Inc., San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James M.","family":"Frincke","sequence":"additional","affiliation":[{"name":"Hollis-Eden Pharmaceuticals, Inc., San Diego, California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.10.3180-3184.2002"},{"key":"e_1_3_2_3_2","first-page":"1","volume":"41","year":"1992","unstructured":"Centers for Disease Control and Prevention. 1992. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. 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