{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T20:49:09Z","timestamp":1780433349880,"version":"3.54.1"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T00:00:00Z","timestamp":1714608000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100011501","name":"Qinghai Provincial Department of Science and Technology","doi-asserted-by":"crossref","award":["2019-SF-131, 2020-ZJ-Y01, 2022-QY-201"],"award-info":[{"award-number":["2019-SF-131, 2020-ZJ-Y01, 2022-QY-201"]}],"id":[{"id":"10.13039\/501100011501","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2024,5,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              Albendazole (ABZ) is the primary treatment for alveolar echinococcosis (AE); however, its limited solubility impacts oral bioavailability, affecting therapeutic outcomes. In this study, various ABZ-solubilizing formulations, including albendazole crystal dispersion system (ABZ-CSD), albendazole hydrochloride-hydroxypropyl methylcellulose phthalate composite (T\n              <jats:sub>ABZ-HCl-H<\/jats:sub>\n              ), and albendazole hydroxyethyl sulfonate-hydroxypropyl methylcellulose phthalate composite (T\n              <jats:sub>ABZ-HES-H<\/jats:sub>\n              ), were developed and evaluated. Physicochemical properties as well as liver enzyme activity were analyzed and their pharmacodynamics in an anti-secondary hepatic alveolar echinococcosis (HAE) rat model were investigated. The formulations demonstrated improved solubility, exhibiting enhanced inhibitory effects on microcysts in HAE model rats compared to albendazole tablets. However, altered hepatic drug-metabolizing enzymes in HAE model rats led to increased ABZ levels and reduced ABZ-SO production, potentially elevating drug toxicity. These findings emphasize the importance of dose adjustments in patient administration, considering the impact of alveolar echinococcosis on rat hepatic drug metabolism.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aac.01449-23","type":"journal-article","created":{"date-parts":[[2024,3,19]],"date-time":"2024-03-19T12:01:08Z","timestamp":1710849668000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Metabolic mechanism and pharmacological study of albendazole in secondary hepatic alveolar echinococcosis (HAE) model rats"],"prefix":"10.1128","volume":"68","author":[{"given":"Chaoqun","family":"Li","sequence":"first","affiliation":[{"name":"Research Center for High Altitude Medicine, Key Laboratory of High Altitude Medicine (Registry of Education), Key Laboratory of Application and Foundation for High Altitude Medicine Research in Qinghai Province (Qinghai Utah Joint Research Key Lab for High Altitude Medicine), Qinghai University, Xining, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaogang","family":"zhang","sequence":"additional","affiliation":[{"name":"Central Laboratory, Affiliated Hospital, Qinghai University, Xining, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingquan","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery, Affiliated Hospital, Qinghai University, Xining, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8314-547X","authenticated-orcid":false,"given":"Chunhui","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plateau Ecology and Agriculture, Qinghai University, Xining, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5313-5732","authenticated-orcid":false,"given":"Haining","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Hepatopancreatobiliary Surgery, Affiliated Hospital, Qinghai University, Xining, China"},{"name":"The Research Key Laboratory for Echinococcosis of Qinghai Province, Xining, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","first-page":"754","article-title":"\u00c9chinococcose alv\u00e9olaire","volume":"70","author":"Vuitton DA","year":"2020","unstructured":"Vuitton DA, Mantion G, Million L, Bresson-Hadni S. 2020. \u00c9chinococcose alv\u00e9olaire. 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