{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:35:59Z","timestamp":1790674559230,"version":"4.1.0"},"reference-count":57,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            In\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacteriaceae<\/jats:named-content>\n            , the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>NDM<\/jats:sub>\n            genes have been found in many different genetic contexts, and a wide diversity of plasmid scaffolds bearing those genes has been found. In August 2013, we identified NDM-1-producing\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Escherichia coli<\/jats:named-content>\n            and\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacter hormaechei<\/jats:named-content>\n            strains from a single rectal swab sample from a patient hospitalized in Rio de Janeiro, Brazil, who had no history of travel abroad. Complete DNA sequencing using the Illumina platform and annotation of the two plasmids harboring the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>NDM-1<\/jats:sub>\n            gene, one from each strain, showed that they belonged to incompatibility groups IncFII\n            <jats:sub>K<\/jats:sub>\n            and IncX3 and harbored a novel transposon named Tn\n            <jats:italic>3000<\/jats:italic>\n            . Similar genetic structures have been identified among other isolates in Brazil but also on plasmids from other continents. Our findings suggest that the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>NDM-1<\/jats:sub>\n            gene may be transmitted by Tn\n            <jats:italic>3000<\/jats:italic>\n            in different parts of the world.\n          <\/jats:p>","DOI":"10.1128\/aac.01458-15","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T02:23:49Z","timestamp":1442888629000},"page":"7387-7395","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":88,"title":["Characterization of Tn\n            <i>3000<\/i>\n            , a Transposon Responsible for\n            <i>bla<\/i>\n            <sub>NDM-1<\/sub>\n            Dissemination among Enterobacteriaceae in Brazil, Nepal, Morocco, and India"],"prefix":"10.1128","volume":"59","author":[{"given":"Juliana Coutinho","family":"Campos","sequence":"first","affiliation":[{"name":"School of Pharmacy, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Jos\u00e9 F\u00e9lix","family":"da Silva","sequence":"additional","affiliation":[{"name":"Fleury Group, Microbiology Section, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Roberto Nascimento","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Children's Hospital, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine Menezes","family":"Barros","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayne de Oliveira","family":"Pereira","sequence":"additional","affiliation":[{"name":"School of Pharmacy, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna Mara 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lio de","family":"Faria-J\u00fanior","sequence":"additional","affiliation":[{"name":"N\u00facleo de Bacteriologia, GBM\/Laborat\u00f3rio Central de Sa\u00fade P\u00fablica, Lacen-Brasilia, Bras\u00edlia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise Teixeira","family":"Cerdeira","sequence":"additional","affiliation":[{"name":"Core Facility for Scientific Research, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afonso Lu\u00eds","family":"Barth","sequence":"additional","affiliation":[{"name":"Research Laboratory of Bacterial Resistance, Experimental Research Center, Clinical Hospital of Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suely Carlos 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