{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:31:16Z","timestamp":1789651876443,"version":"4.0.0"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            New antibiotics are required to have the antibacterial activity against doxycycline-resistant\n            <jats:italic>Orientia tsutsugamushi<\/jats:italic>\n            . An in vitro sensitivity study showed that telithromycin was more effective than erythromycin for\n            <jats:italic>Rickettsia<\/jats:italic>\n            ,\n            <jats:italic>Bartonella<\/jats:italic>\n            , and\n            <jats:italic>Coxiella burnetii<\/jats:italic>\n            . In this prospective, open-label, randomized trial, we enrolled patients with mild-to-moderate scrub typhus. We compared the efficacy and safety of a 5-day telithromycin therapy with those of a 5-day doxycycline therapy at Chosun University Hospital or one of its two community-based affiliated hospitals (Jangheung Hospital and Cheomdan Hospital), which are all located in southwestern Korea, between September and December 2005. A total of 92 patients were randomly assigned to either the telithromycin group (\n            <jats:italic>n<\/jats:italic>\n            = 47) or the doxycycline group (\n            <jats:italic>n<\/jats:italic>\n            = 45). After the treatment, fever control time was 20.45 \u00b1 12.9 h in the telithromycin group and 22.60 \u00b1 21.44 h in the doxycycline group (\n            <jats:italic>P<\/jats:italic>\n            &gt; 0.05). After the treatment, the cure rate was 100% in the telithromycin group and 97.8% in the doxycycline group (\n            <jats:italic>P<\/jats:italic>\n            &gt; 0.05). Furthermore, there were no significant differences in time elapsed until such symptoms as headache, myalgia, and rash disappeared. No serious adverse events or death were noted following the treatment in both groups. There were no significant differences in adverse events. In conclusion, the efficacy and safety of a 5-day once-a-day regimen of 800 mg telithromycin were equivalent to those of a 5-day twice-a-day regimen of 100 mg doxycycline in patients with mild-to-moderate scrub typhus. Telithromycin could be considered a promising new antibacterial agent for patients with scrub typhus.\n          <\/jats:p>","DOI":"10.1128\/aac.01460-06","type":"journal-article","created":{"date-parts":[[2007,4,3]],"date-time":"2007-04-03T00:54:34Z","timestamp":1175561674000},"page":"2011-2015","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":35,"title":["Controlled Trial of a 5-Day Course of Telithromycin versus Doxycycline for Treatment of Mild to Moderate Scrub Typhus"],"prefix":"10.1128","volume":"51","author":[{"given":"Dong-Min","family":"Kim","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Chosun University College of Medicine, Gwangju"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki Dong","family":"Yu","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Chosun University College of Medicine, Gwangju"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Jangheung General Hospital, Jangheung"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Kuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Cheomdan General Hospital, Gwangju"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Seonam University College of Medicine, Namwon, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-145-6-200609190-00016"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(82)90024-1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365549709035911"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/517742"},{"key":"e_1_3_2_6_2","first-page":"433","volume":"23","year":"2000","unstructured":"Chung, M. H., S. W. Han, M. G. Choi, W. H. Chang, H. J. Pai, H. S. Shin, H. J. Jung, M. H. Kang, and J. Y. Jung. 2000. Comparison of a 3-day course of azithromycin with doxycycline for the treatment of scrub typhus. Korean J. Infect. Dis.23:433-438.","journal-title":"Korean J. Infect. Dis."},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-144-6-200503210-00121"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/3.3.479"},{"key":"e_1_3_2_9_2","first-page":"475","volume":"92","year":"1993","unstructured":"Hsu, G. J., T. Young, M. Y. Peng, F. Y. Chang, M. Y. Chou, and L. F. Sheu. 1993. Acute renal failure associated with scrub typhus: report of a case. J. Formos. Med. Assoc.92:475-477.","journal-title":"J. Formos. Med. Assoc."},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.4269\/ajtmh.2006.75.542"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/425008"},{"key":"e_1_3_2_12_2","first-page":"130","volume":"22","year":"2003","unstructured":"Lee, K. Y., H. S. Lee, J. H. Hong, J. K. Hur, and K. T. Whang. 2003. Roxithromycin treatment of scrub typhus (tsutsugamushi disease) in children. Pediatr. Infect. Dis. J.22:130-133.","journal-title":"Pediatr. Infect. Dis. J."},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.44.3.1169-1171.2006"},{"key":"e_1_3_2_14_2","first-page":"39","volume":"38","year":"2006","unstructured":"Lim, J. H., S. Y. Lee, J. S. Lee, S. Chil, E. S. Kim, M. H. Chung, J. S. Kang, J. H. Lee, Y. K. Cho, and S. O. Lee. 2006. A preliminary report on the clinical efficacy of telithromycin for the treatment of scrub typhus. Korean J. Infect. Dis.38:39-44.","journal-title":"Korean J. Infect. 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