{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:37:40Z","timestamp":1790797060041,"version":"4.1.0"},"reference-count":18,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>We studied the penetration of raltegravir and HIV shedding in the genital tract among 14 HIV-1-infected women receiving a raltegravir-containing regimen who had &lt;40 copies\/ml blood plasma (BP) HIV RNA. None of the cervicovaginal fluid (CVF) samples showed detectable HIV RNA. Median raltegravir concentrations were 235 ng\/ml in BP and 93 ng\/ml in CVF, with a CVF\/BP ratio of approximately 2.3. This good penetration of raltegravir may contribute to the control of viral replication in the female genital tract.<\/jats:p>","DOI":"10.1128\/aac.01460-10","type":"journal-article","created":{"date-parts":[[2011,3,29]],"date-time":"2011-03-29T02:09:32Z","timestamp":1301364572000},"page":"3018-3021","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":31,"title":["Raltegravir Concentrations in the Genital Tract of HIV-1-Infected Women Treated with a Raltegravir-Containing Regimen (DIVA 01 Study)"],"prefix":"10.1128","volume":"55","author":[{"given":"Cyril","family":"Clavel","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, and INSERM U 943, Assistance Publique H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Peytavin","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Bichat Claude-Bernard Hospital, Assistance Publique H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Tubiana","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, and INSERM U 943, Assistance Publique H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathia","family":"Souli\u00e9","sequence":"additional","affiliation":[{"name":"Department of Virology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, and INSERM U 943, Assistance Publique H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Crenn-Hebert","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Louis Mourier Hospital, Assistance Publique H\u00f4pitaux de Paris, and University of Paris-Diderot, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Heard","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, and INSERM U 943, Assistance Publique H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Bissuel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Centre Hospitalier Louis Constant Fleming, Saint-Martin, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houria","family":"Ichou","sequence":"additional","affiliation":[{"name":"Department of Virology, Louis Mourier Hospital, Assistance Publique H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Louis Mourier Hospital, Assistance Publique H\u00f4pitaux de Paris, and University of Paris-Diderot, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Katlama","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, and INSERM U 943, Assistance Publique H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Genevi\u00e8ve","family":"Marcelin","sequence":"additional","affiliation":[{"name":"Department of Virology, Piti\u00e9-Salp\u00eatri\u00e8re Hospital, and INSERM U 943, Assistance Publique H\u00f4pitaux de Paris, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Mandelbrot","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Louis Mourier Hospital, Assistance Publique H\u00f4pitaux de Paris, and University of Paris-Diderot, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01261-09"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-4-17"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002030-200003100-00015"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00126334-200309010-00005"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181ae69c5"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e328270385a"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn098"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/596503"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100281"},{"key":"e_1_3_2_11_2","volume-title":"10th Int. 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