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We have evaluated the efficacy of amphotericin B at 0.8 mg\/kg or 0.3 mg\/kg of body weight combined with 40 mg\/kg of posaconazole against three\n A. fumigatus<\/jats:named-content>\n isolates in a murine model of disseminated infection. The combination of the polyene and the azole led to a greater increase in survival and a significantly greater reduction in tissue burden than monotherapies.\n <\/jats:p>","DOI":"10.1128\/aac.01462-15","type":"journal-article","created":{"date-parts":[[2015,10,27]],"date-time":"2015-10-27T02:34:05Z","timestamp":1445913245000},"page":"296-300","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":12,"title":["In Vivo<\/i>\n Synergy of Amphotericin B plus Posaconazole in Murine Aspergillosis"],"prefix":"10.1128","volume":"60","author":[{"given":"Adela","family":"Martin-Vicente","sequence":"first","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Capilla","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Guarro","sequence":"additional","affiliation":[{"name":"Unitat de Microbiologia, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Tarragona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783X-16-4-153"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/595846"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21488"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2010-0290"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/525258"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22348"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000202421.94822.f7"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02809-13"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2014.08.012"},{"key":"e_1_3_1_11_2","doi-asserted-by":"publisher","DOI":"10.7326\/M13-2508"},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiac.2014.08.010"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/423380"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.3.758-764.2004"},{"key":"e_1_3_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks402"},{"key":"e_1_3_1_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01331-12"},{"key":"e_1_3_1_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00563-13"},{"key":"e_1_3_1_18_2","volume-title":"CLSI document M38-A2","author":"Clinical and Laboratory Standards Institute","year":"2008","unstructured":"Clinical and Laboratory Standards Institute. 2008. 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