{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:28:17Z","timestamp":1787783297809,"version":"build-2784847793"},"reference-count":30,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Albendazole is an anthelmintic drug widely used in the treatment of neurocysticercosis (NCC), an infection of the brain with<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Taenia solium<\/jats:named-content>cysts. However, drug levels of its active metabolite, albendazole sulfoxide (ABZSO), are erratic, likely resulting in decreased efficacy and suboptimal cure rates in NCC. Racemic albendazole sulfoxide is composed of ABZSO (+)-(<jats:italic>R<\/jats:italic>)- and (\u2212)-(<jats:italic>S<\/jats:italic>) enantiomers that have been shown to differ in pharmacokinetics and activity against other helminths. The antiparasitic activities of racemic ABZSO and its (+)-(<jats:italic>R<\/jats:italic>)- and (\u2212)-(<jats:italic>S<\/jats:italic>) enantiomers against<jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">T. solium<\/jats:named-content>cysts were evaluated<jats:italic>in vitro<\/jats:italic>. Parasites were collected from naturally infected pigs, cultured, and exposed to the racemic mixture or to each enantiomer (range, 10 to 500 ng\/ml) or to praziquantel as a reference drug. The activity of each compound against cysts was assayed by measuring the ability to evaginate and inhibition of alkaline phosphatase (AP) and parasite antigen release. (+)-(<jats:italic>R<\/jats:italic>)-ABZSO was significantly more active than (\u2212)-(<jats:italic>S<\/jats:italic>)-ABZSO in suppressing the release of AP and antigen into the supernatant in a dose- and time-dependent manner, indicating that most of the activity of ABZSO resides in the (+)-(<jats:italic>R<\/jats:italic>) enantiomer. Use of this enantiomer alone may lead to increased efficacy and\/or less toxicity compared to albendazole.<\/jats:p>","DOI":"10.1128\/aac.01465-12","type":"journal-article","created":{"date-parts":[[2012,12,11]],"date-time":"2012-12-11T04:15:05Z","timestamp":1355199305000},"page":"944-949","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["<i>In Vitro<\/i>Analysis of Albendazole Sulfoxide Enantiomers Shows that (+)-(<i>R<\/i>)-Albendazole Sulfoxide Is the Active Enantiomer against Taenia solium"],"prefix":"10.1128","volume":"57","author":[{"given":"Adriana","family":"Paredes","sequence":"first","affiliation":[{"name":"Laboratorio de Inmunopatolog\u00eda en Neurocisticercosis, Facultad de Ciencias y Filosof\u00eda, Universidad Peruana Cayetano Heredia, Lima, Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"de Campos 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