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Clinical isolates of\n                    <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n                    are often resistant to one or more antifungal agents. To explore how antifungal resistance develops, we performed experimental evolution assays using a fluconazole-susceptible isolate of\n                    <jats:named-content content-type=\"genus-species\">C. auris<\/jats:named-content>\n                    (BJCA001). After a series of passages through medium containing increasing concentrations of fluconazole, fungal cells acquired resistance.\n                  <\/jats:p>","DOI":"10.1128\/aac.01466-20","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T09:41:06Z","timestamp":1603186866000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":85,"title":["Experimental Evolution Identifies Adaptive Aneuploidy as a Mechanism of Fluconazole Resistance in Candida auris"],"prefix":"10.1128","volume":"65","author":[{"given":"Jian","family":"Bing","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Huashan Hospital, and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianren","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Huashan Hospital, and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China"},{"name":"State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushi","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4987-7957","authenticated-orcid":false,"given":"Jos\u00e9 F.","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5778-960X","authenticated-orcid":false,"given":"Christina A.","family":"Cuomo","sequence":"additional","affiliation":[{"name":"Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4761-7548","authenticated-orcid":false,"given":"Guanghua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Huashan Hospital, and State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01588-17"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000469"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw691"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006290"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12904"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.7326\/M19-2205"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-016-0132-5"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myw147"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12781"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-17"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07779-6"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2660475"},{"key":"e_1_3_3_14_2","first-page":"43","article-title":"Genomic epidemiology of the UK outbreak of the emerging human fungal pathogen Candida auris","volume":"7","author":"Rhodes J","year":"2018","unstructured":"Rhodes J, Abdolrasouli A, Farrer RA, Cuomo CA, Aanensen DM, Armstrong-James D, Fisher MC, Schelenz S. 2018. 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