{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T20:39:42Z","timestamp":1775248782406,"version":"3.50.1"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Human studies support the use of \u03b2-lactams and tetracyclines in the treatment of leptospirosis. Additional agents from these and other classes of antimicrobials also have in vitro activity against<jats:italic>Leptospira<\/jats:italic>species, though corroborating in vivo data are limited or lacking. We evaluated the therapeutic efficacy of azithromycin, clarithromycin, and telithromycin in a lethal hamster model of leptospirosis using<jats:italic>Leptospira interrogans<\/jats:italic>serogroup Canicola serovar Portlandvere. A range of dosages for each antimicrobial was given to the infected animals on days 2 through 7 (5 days) of the 21-day survival model. All untreated control animals survived less than 10 days from infection. Ninety to 100% of doxycycline controls, treated for 5 days with 5 mg\/kg of body weight of drug, survived to 21 days. Treatment with azithromycin (daily dose: 6.25, 12.5, 25, 50, 100, or 200 mg\/kg) resulted in 100% survival at all evaluated doses. Animals receiving 20 mg\/kg or more of clarithromycin (daily dose: 1, 5, 10, 15, 20, 40, 60, or 100 mg\/kg) had improved survival. Ninety-eight percent of animals treated with telithromycin (daily dose: 1, 5, 10, 15, 20, or 40 mg\/kg) survived. We conclude that all agents tested have demonstrated in vivo efficacy in treating acute leptospirosis. These results provide support for further evaluation of macrolide and ketolide antimicrobial agents in human trials.<\/jats:p>","DOI":"10.1128\/aac.01467-05","type":"journal-article","created":{"date-parts":[[2006,5,24]],"date-time":"2006-05-24T21:13:58Z","timestamp":1148505238000},"page":"1989-1992","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":20,"title":["Efficacy of Macrolides and Telithromycin against Leptospirosis in a Hamster Model"],"prefix":"10.1128","volume":"50","author":[{"given":"James E.","family":"Moon","sequence":"first","affiliation":[{"name":"Department of Medicine and Department of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael C.","family":"Ellis","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew E.","family":"Griffith","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua S.","family":"Hawley","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert G.","family":"Rivard","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"McCall","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duane R.","family":"Hospenthal","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clinton K.","family":"Murray","sequence":"additional","affiliation":[{"name":"Department of Medicine and Department of Clinical Investigation, Brooke Army Medical Center, Fort Sam Houston, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.30.6.835"},{"key":"e_1_3_2_3_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2460\/ajvr.1996.57.01.59","volume":"57","year":"1996","unstructured":"Alt, D. 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