{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:18:54Z","timestamp":1791839934048,"version":"4.3.4"},"reference-count":77,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI144498"],"award-info":[{"award-number":["R21AI144498"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI148890"],"award-info":[{"award-number":["R21AI148890"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["R21AI150641"],"award-info":[{"award-number":["R21AI150641"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2022,1,18]]},"abstract":"<jats:p>\n                    <jats:named-content content-type=\"genus-species\">Candida albicans<\/jats:named-content>\n                    causes life-threatening disseminated candidiasis. Individuals at greatest risk have weakened immune systems.\n                  <\/jats:p>","DOI":"10.1128\/aac.01467-21","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T13:20:05Z","timestamp":1633958405000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":22,"title":["DectiSomes: Glycan Targeting of Liposomal Drugs Improves the Treatment of Disseminated Candidiasis"],"prefix":"10.1128","volume":"66","author":[{"given":"Suresh","family":"Ambati","sequence":"first","affiliation":[{"name":"Department of Genetics, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuyetnhu","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1735-8266","authenticated-orcid":true,"given":"Zachary A.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3390-8387","authenticated-orcid":true,"given":"Xiaorong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3928-8403","authenticated-orcid":true,"given":"Richard B.","family":"Meagher","sequence":"additional","affiliation":[{"name":"Department of Genetics, University of Georgia, Athens, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","unstructured":"CDC. 2019. Antibiotic\/Antimicrobial Resistance (AR\/AMR). https:\/\/www.cdc.gov\/drugresistance\/biggest-threats.html."},{"key":"e_1_3_3_3_2","first-page":"1","article-title":"Global and multi-national prevalence of fungal diseases-estimate precision","volume":"3","author":"Bongomin F","year":"2017","unstructured":"Bongomin F, Gago S, Oladele RO, Denning DW. 2017. Global and multi-national prevalence of fungal diseases-estimate precision. J Fungi (Basel) 3:1\u201329.","journal-title":"J Fungi (Basel)"},{"key":"e_1_3_3_4_2","unstructured":"CDC. 2020. Candidiasis. https:\/\/www.cdc.gov\/fungal\/diseases\/candidiasis\/index.html."},{"key":"e_1_3_3_5_2","volume-title":"Antifungal drugs: Technologies and global markets.","author":"Taylor P","year":"2020","unstructured":"Taylor P. 2020. Antifungal drugs: Technologies and global markets. BCC Research LLC, Publishing B."},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid2301.161198"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myy136"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2005.05.015"},{"key":"e_1_3_3_9_2","first-page":"337","article-title":"Triple antifungal therapy for severe systemic candidiasis allowed performance of allogeneic stem cell transplantation","volume":"12","author":"Gahn B","year":"2007","unstructured":"Gahn B, Schub N, Repp R, Gramatzki M. 2007. Triple antifungal therapy for severe systemic candidiasis allowed performance of allogeneic stem cell transplantation. Eur J Med Res 12:337\u2013340.","journal-title":"Eur J Med Res"},{"key":"e_1_3_3_10_2","first-page":"39","article-title":"Clinical characteristics and outcomes in 303 HIV-infected patients with invasive fungal infections: data from the Prospective Antifungal Therapy Alliance registry, a multicenter, observational study","volume":"6","author":"Marukutira T","year":"2014","unstructured":"Marukutira T, Huprikar S, Azie N, Quan S-P, Meier-Kriesche H-U, Horn DL. 2014. Clinical characteristics and outcomes in 303 HIV-infected patients with invasive fungal infections: data from the Prospective Antifungal Therapy Alliance registry, a multicenter, observational study. HIV\/AIDS (Auckland, NZ) 6:39\u201347.","journal-title":"HIV\/AIDS (Auckland, NZ)"},{"key":"e_1_3_3_11_2","first-page":"204","article-title":"Profile of candidiasis in HIV infected patients","volume":"4","author":"Anwar KP","year":"2012","unstructured":"Anwar KP, Malik A, Subhan KH. 2012. Profile of candidiasis in HIV infected patients. Iran J Microbiol 4:204\u2013209.","journal-title":"Iran J Microbiol"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-016-0538-7"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066906"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.14655"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-009-0843-0"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-018-1152-2"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy776"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vhri.2019.07.002"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12071"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof6010023"},{"key":"e_1_3_3_21_2","first-page":"97","article-title":"Treatment of invasive candidiasis: a narrative review","volume":"4","author":"Ben-Ami R","year":"2018","unstructured":"Ben-Ami R. 2018. Treatment of invasive candidiasis: a narrative review. J Fungi (Basel, Switzerland) 4:97.","journal-title":"J Fungi (Basel, Switzerland)"},{"key":"e_1_3_3_22_2","unstructured":"CDC. 2018. Fungal diseases: Aspergillus. https:\/\/wwwcdcgov\/fungal\/diseases\/aspergillosis\/definitionhtml."},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02573"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S185833"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap7999"},{"key":"e_1_3_3_27_2","first-page":"603","article-title":"Antifungal agents for the treatment of systemic fungal infections in children","volume":"15","author":"Allen U","year":"2010","unstructured":"Allen U. 2010. Antifungal agents for the treatment of systemic fungal infections in children. Paediatr Child Health 15:603\u2013608. https:\/\/academic.oup.com\/pch\/article\/15\/9\/603\/2639452.","journal-title":"Paediatr Child Health"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.suppl_1.31"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12802"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00458-19"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.000757"},{"key":"e_1_3_3_32_2","first-page":"1","article-title":"Dectin-2-targeted antifungal liposomes exhibit enhanced efficacy","volume":"4","author":"Ambati S","year":"2019","unstructured":"Ambati S, Ellis EC, Lin J, Lin X, Lewis ZA, Meagher RB. 2019. Dectin-2-targeted antifungal liposomes exhibit enhanced efficacy. mSphere 4:1\u201316.","journal-title":"mSphere"},{"key":"e_1_3_3_33_2","first-page":"1","article-title":"Dectin-1-targeted antifungal liposomes exhibit enhanced efficacy","volume":"4","author":"Ambati S","year":"2019","unstructured":"Ambati S, Ferarro AR, Kang SE, Lin J, Lin X, Momany M, Lewis ZA, Meagher RB. 2019. Dectin-1-targeted antifungal liposomes exhibit enhanced efficacy. mSphere 4:1\u201315.","journal-title":"mSphere"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009699"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00451-18"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00030-21"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0040035"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01061-07"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.2.674-684.2006"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.4895-4902.2005"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.3.922-926.2001"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofw241"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.2165\/11585270-000000000-00000"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01584-09"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.36984"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.41.6.1345"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.5.1240-1245.2002"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2014.11.021"},{"key":"e_1_3_3_49_2","first-page":"297","article-title":"Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential","volume":"1","author":"Immordino ML","year":"2006","unstructured":"Immordino ML, Dosio F, Cattel L. 2006. Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential. Int J Nanomedicine (Lond) 1:297\u2013315.","journal-title":"Int J Nanomedicine (Lond)"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(91)90201-i"},{"key":"e_1_3_3_51_2","first-page":"1","article-title":"Understanding the nanotechnology in COVID-19 vaccines","volume":"18","author":"Tenchov R","year":"2021","unstructured":"Tenchov R. 2021. Understanding the nanotechnology in COVID-19 vaccines. CAS February 18:1\u201315. https:\/\/www.cas.org\/resource\/blog\/understanding-nanotechnology-covid-19-vaccines.","journal-title":"CAS"},{"key":"e_1_3_3_52_2","doi-asserted-by":"crossref","unstructured":"Saijo S Ikeda S Yamabe K Kakuta S Ishigame H Akitsu A Fujikado N Kusaka T Kubo S Chung SH Komatsu R Miura N Adachi Y Ohno N Shibuya K Yamamoto N Kawakami K Yamasaki S Saito T Akira S Iwakura Y. 2010. Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans . Immunity 32:681\u201391.","DOI":"10.1016\/j.immuni.2010.05.001"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01612-14"},{"key":"e_1_3_3_54_2","first-page":"721","article-title":"The critical role of Dectin-1 in host controlling systemic Candida krusei infection","volume":"11","author":"Chen SM","year":"2019","unstructured":"Chen SM, Zou Z, Qiu XR, Hou WT, Zhang Y, Fang W, Chen YL, Wang YD, Jiang YY, Shen H, An MM. 2019. The critical role of Dectin-1 in host controlling systemic Candida krusei infection. Am J Transl Res 11:721\u2013732.","journal-title":"Am J Transl Res"},{"key":"e_1_3_3_55_2","doi-asserted-by":"crossref","unstructured":"Yang M Solis NV Marshall M Garleb R Zhou T Wang D Swidergall M Pearlman E Filler SG Liu H. 2020. Control of \u03b2-glucan exposure by the endo-1 3-glucanase Eng1 in Candida albicans modulates virulence. bioRxiv 10.1101\/2020.09.07.285791:2020.09.07.285791.","DOI":"10.1101\/2020.09.07.285791"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01874-14"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01318-18"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.01800"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00294-013-0400-3"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.13.101"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0507.2011.02149.x"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.17.2.255-267.2004"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.6.1773-1780.2002"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1089\/cdd.1984.1.199"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(84)90135-4"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/35.4.509"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02383-17"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1086\/514704"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1080\/23744235.2019.1568546"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00366-11"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31817275e6"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.3.614-618.2000"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00156-10"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/134.3.717"},{"key":"e_1_3_3_75_2","unstructured":"www.gpo.gov. 2012. US Code Title 7: Chapter 54\u2014Transportation sale and handling of certain animals. http:\/\/www.gpo.gov\/fdsys\/browse\/collectionUScode.action?collectionCode=USCODE&searchPath=Title+7%2FCHAPTER+54&oldPath=Title+7%2FCHAPTER+55A&isCollapsed=true&selectedYearFrom=2012&ycord=2250."},{"key":"e_1_3_3_76_2","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_3_3_77_2","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.1998.11747226"},{"key":"e_1_3_3_78_2","unstructured":"Meagher RB Lewis ZA Lin X Ambati S Momany M. 2019. Targeted nanoparticles and their uses related to fungal infections. United StatesWO\/2020\/146514. https:\/\/patentscope.wipo.int\/search\/en\/detail.jsf?docId=WO2020146514&_cid=P11-KHDI99-36314-1."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01467-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01467-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T18:39:56Z","timestamp":1645468796000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01467-21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,18]]},"references-count":77,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1,18]]}},"alternative-id":["10.1128\/AAC.01467-21"],"URL":"https:\/\/doi.org\/10.1128\/aac.01467-21","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.07.27.454088","asserted-by":"object"}]},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,18]]},"assertion":[{"value":"2021-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01467-21"}}