{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:17:11Z","timestamp":1791181031227,"version":"4.1.0"},"reference-count":38,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2007,9,1]],"date-time":"2007-09-01T00:00:00Z","timestamp":1188604800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Bacterial adaptation to external stresses and toxic compounds is a key step in the emergence of multidrug-resistant strains that are a serious threat to human health. Although some of the proteins and regulators involved in antibiotic resistance mechanisms have been described, no information is available to date concerning the early bacterial response to external stresses. Here we report that the expression of\n            <jats:italic>ompX<\/jats:italic>\n            , encoding an outer membrane protein, is increased during early exposure to drugs or environmental stresses. At the same time, the level of\n            <jats:italic>ompF<\/jats:italic>\n            porin expression is noticeably affected. Because of the role of these proteins in membrane permeability, these data suggest that OmpF and OmpX are involved in the control of the penetration of antibiotics such as \u03b2-lactams and fluoroquinolones through the enterobacterial outer membrane. Consequently, the early control of\n            <jats:italic>ompX<\/jats:italic>\n            and\n            <jats:italic>ompF<\/jats:italic>\n            induced by external stresses may represent a preliminary response to antibiotics, thus triggering the initial bacterial line of defense against antibiotherapy.\n          <\/jats:p>","DOI":"10.1128\/aac.01481-06","type":"journal-article","created":{"date-parts":[[2007,7,3]],"date-time":"2007-07-03T00:39:36Z","timestamp":1183423176000},"page":"3190-3198","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":68,"title":["An Early Response to Environmental Stress Involves Regulation of OmpX and OmpF, Two Enterobacterial Outer Membrane Pore-Forming Proteins"],"prefix":"10.1128","volume":"51","author":[{"given":"Myrielle","family":"Dupont","sequence":"first","affiliation":[{"name":"UMR-MD1, IFR48, Faculte\u0301s de Me\u0301decine et de Pharmacie, Universite\u0301 de la Me\u0301diterrane\u0301e, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe\u0308 E.","family":"James","sequence":"additional","affiliation":[{"name":"UMR-MD1, IFR48, Faculte\u0301s de Me\u0301decine et de Pharmacie, Universite\u0301 de la Me\u0301diterrane\u0301e, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Chevalier","sequence":"additional","affiliation":[{"name":"UMR-MD1, IFR48, Faculte\u0301s de Me\u0301decine et de Pharmacie, Universite\u0301 de la Me\u0301diterrane\u0301e, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Page\u0300s","sequence":"additional","affiliation":[{"name":"UMR-MD1, IFR48, Faculte\u0301s de Me\u0301decine et de Pharmacie, Universite\u0301 de la Me\u0301diterrane\u0301e, Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2006.12.029"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1997.3151679.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.182.12.3467-3474.2000"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.176.17.5537-5540.1994"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.37.7.2165-2169.1999"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.40.4.1237-1243.2002"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.4.1093-1097.2002"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.39.3.889-896.2001"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.05.047"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.5.1555-1559.2003"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.17.5532-5538.1991"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2001.02358.x"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.9.3955-3958.2005"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.179.9.2872-2878.1997"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.42.8.3805-3808.2004"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0161-5890(89)90067-9"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1099\/00221287-144-11-3003"},{"key":"e_1_3_2_19_2","first-page":"273","volume":"129","year":"1995","unstructured":"Mall\u00e9a, M., V. Simonet, E. H. Lee, R. Gervier, E. Collatz, L. Gutmann, and J. M. Pag\u00e8s. 1995. Biological and immunological comparisons of Enterobacter cloacae and Escherichia coli porins. FEMS Microbiol. Lett.129:273-279.","journal-title":"FEMS Microbiol. Lett."},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.187.11.3894-3897.2005"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.177.3.799-804.1995"},{"key":"e_1_3_2_22_2","unstructured":"Experiments in molecular genetics 1972"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.15.4161-4167.2002"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.67.4.593-656.2003"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.5.1423-1429.2004"},{"key":"e_1_3_2_26_2","first-page":"41","year":"2004","unstructured":"Pag\u00e8s, J. M. 2004. Role of bacterial porins in antibiotic susceptibility of gram-negative bacteria. p. 41-59. In R. Benz (ed.), Bacterial and eukaryotic porins: structure, function, mechanism. Wiley-VCH (ed.), New York, NY.","journal-title":"Bacterial and eukaryotic porins: structure, function, mechanism"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05524.x"},{"key":"e_1_3_2_28_2","first-page":"S20","volume":"119","year":"2006","unstructured":"Paterson, D. L. 2006. Resistance in gram-negative bacteria: Enterobacteriaceae. Am. J. Med.119:S20-S28; S62-S70.","journal-title":"Am. J. Med."},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.183.13.3890-3902.2001"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.18.5631-5638.1991"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.5.1407-1416.2002"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro1394"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.184.15.4246-4258.2002"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.69.1.183"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.1.161-167.1991"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/jb.178.12.3650-3653.1996"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.4.1354-1358.2005"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2007.03.001"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000365"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01481-06","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01481-06","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T19:26:52Z","timestamp":1645471612000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01481-06"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9]]},"references-count":38,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2007,9]]}},"alternative-id":["10.1128\/AAC.01481-06"],"URL":"https:\/\/doi.org\/10.1128\/aac.01481-06","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9]]},"assertion":[{"value":"2006-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-06-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2007-09-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}