{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:21:17Z","timestamp":1791354077474,"version":"4.3.1"},"reference-count":31,"publisher":"American Society for Microbiology","issue":"7","license":[{"start":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T00:00:00Z","timestamp":1309478400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Dicationic diamidines, such as diminazene and pentamidine, are well-studied chemotherapeutic agents with significant activity against parasitic diseases. The\n            <jats:italic>in vitro<\/jats:italic>\n            activities of novel diamidine compounds against the\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Babesia divergens<\/jats:named-content>\n            strains 1903B and 4201 were investigated. The most potent compound, a diphenyl furan, had a 50% inhibitory concentration (IC\n            <jats:sub>50<\/jats:sub>\n            ) of 1.5 ng\/ml. In a murine model, several test compounds were effective enough to cure mice infected with\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Babesia microti<\/jats:named-content>\n            at a dose of 12.5 and\/or 25 mg\/kg of body weight given by the subcutaneous route for 4 days. The best antibabesial properties were exhibited by terphenyls, benzimidazoles, diphenyl furans, pentamidine, and pentamidine analogues.\n          <\/jats:p>","DOI":"10.1128\/aac.01482-10","type":"journal-article","created":{"date-parts":[[2011,5,3]],"date-time":"2011-05-03T02:42:03Z","timestamp":1304390523000},"page":"3439-3445","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Novel Diamidines with Activity against Babesia divergens\n            <i>In Vitro<\/i>\n            and Babesia microti\n            <i>In Vivo<\/i>"],"prefix":"10.1128","volume":"55","author":[{"given":"Angela","family":"Nehrbass-Stuedli","sequence":"first","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Boykin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Georgia State University, Atlanta, Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard R.","family":"Tidwell","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of North Carolina, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Brun","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland"},{"name":"University of Basel, Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","first-page":"5843","article-title":"Synthesis of 5-[2-(5-amidinobenzimidazoyl)-2-(4-amidinophenyl)furan hydrochloride to test a DNA minor groove dimer binding model","volume":"63","author":"Batista-Parra A","year":"2003","unstructured":"Batista-ParraA. 2003. Synthesis of 5-[2-(5-amidinobenzimidazoyl)-2-(4-amidinophenyl)furan hydrochloride to test a DNA minor groove dimer binding model. Diss. Abstr. Int. B 63:5843.","journal-title":"Diss. Abstr. Int. 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