{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T19:28:06Z","timestamp":1776022086652,"version":"3.50.1"},"reference-count":46,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We evaluated and compared the efficacies of different antifungal drugs against\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Sarocladium kiliense<\/jats:named-content>\n            (formerly\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Acremonium kiliense<\/jats:named-content>\n            ), a clinically relevant opportunistic fungus, in a murine model of systemic infection. Three clinical strains of this fungus were tested, and the therapy administered was as follows: posaconazole at 20 mg\/kg of body weight (twice daily), voriconazole at 40 mg\/kg, anidulafungin at 10 mg\/kg, or amphotericin B at 0.8 mg\/kg. The efficacy was evaluated by prolonged animal survival, tissue burden reduction, and (1\u21923)-\u03b2-\n            <jats:sc>d<\/jats:sc>\n            -glucan serum levels. In general, the four antifungal drugs showed high MICs and poor\n            <jats:italic>in vitro<\/jats:italic>\n            activity. The efficacy of the different treatments was only modest, since survival rates were never higher than 40% and no drug was able to reduce fungal load in all the organs for the three strains tested. Posaconazole, in spite of its high MICs (\u226516 \u03bcg\/ml), showed the highest efficacy. The (1\u21923)-\u03b2-\n            <jats:sc>d<\/jats:sc>\n            -glucan serum levels were equally reduced by all drugs evaluated.\n          <\/jats:p>","DOI":"10.1128\/aac.01484-13","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T03:08:58Z","timestamp":1381201738000},"page":"6265-6269","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["Evaluation of the Efficacies of Amphotericin B, Posaconazole, Voriconazole, and Anidulafungin in a Murine Disseminated Infection by the Emerging Opportunistic Fungus Sarocladium (Acremonium)\n            <i>kiliense<\/i>"],"prefix":"10.1128","volume":"57","author":[{"given":"Fabiola","family":"Fern\u00e1ndez-Silva","sequence":"first","affiliation":[{"name":"Unitat d'Anatomia Patol\u00f2gica, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Capilla","sequence":"additional","affiliation":[{"name":"Microbiologia, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio","family":"Mayayo","sequence":"additional","affiliation":[{"name":"Unitat d'Anatomia Patol\u00f2gica, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deanna A.","family":"Sutton","sequence":"additional","affiliation":[{"name":"Fungus Testing Laboratory, University of Texas Health Science Center, San Antonio, Texas, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Estad\u00edstica i Epidemiologia, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Guarro","sequence":"additional","affiliation":[{"name":"Microbiologia, Facultat de Medicina i Ci\u00e8ncies de la Salut, IISPV, Universitat Rovira i Virgili, Reus, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.3114\/sim.2011.68.06"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-010-9334-1"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1086\/516098"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02278-10"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/22.2.222"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.001"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.1998.tb00929.x"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.0007-0963.2004.05896.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1994.171"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1987.tb133355.x"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1988.tb02390.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg040"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/149.4.653"},{"key":"e_1_3_2_15_2","first-page":"554","article-title":"Acremonium kiliense osteomyelitis of the calvarium","volume":"16","author":"Brabender W","year":"1985","unstructured":"BrabenderW KetchersideJ HodgesGR RengacharyS BarnesWG. 1985. 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