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We characterize the evolution of a KPC-8-producing\n                      <jats:italic toggle=\"yes\">Klebsiella pneumoniae<\/jats:italic>\n                      strain involved in a primary infection without previous ceftazidime\/avibactam treatment. During a 15-month follow-up, changes in carbapenem susceptibility due to porin alterations were observed, remaining susceptible to meropenem\/vaborbactam, imipenem\/relebactam, and cefiderocol. High- and low-permeability recombinant\n                      <jats:italic toggle=\"yes\">Escherichia coli<\/jats:italic>\n                      isolates analysis revealed that, unlike the widespread ceftazidime\/avibactam-resistant variant KPC-31, KPC-8 confers ceftazidime\/avibactam resistance without decreasing carbapenemase activity.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01494-24","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T09:02:42Z","timestamp":1745312562000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Emergence of KPC-8-producing\n                    <i>K. pneumoniae<\/i>\n                    infection without prior exposure to ceftazidime\/avibactam: the threat of\n                    <i>de novo<\/i>\n                    infections by ceftazidime\/avibactam-resistant KPC variants"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0854-9703","authenticated-orcid":true,"given":"Mar\u00eda Alejandra","family":"Mateo-Vargas","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04mxxkb11","id-type":"ROR","asserted-by":"publisher"}],"name":"Departamento de Biomedicina, Biotecnolog\u00eda y Salud P\u00fablica, Universidad de C\u00e1diz","place":["Cadiz, Spain"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salud","family":"Rodr\u00edguez-Pallares","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/044knj408","id-type":"ROR","asserted-by":"publisher"}],"name":"Servicio de Microbiolog\u00eda and Instituto de Investigaci\u00f3n Biom\u00e9dica A Coru\u00f1a (INIBIC), Complexo Hospitalario Universitario A Coru\u00f1a, A Coru\u00f1a (Spain)","place":["A Coru\u00f1a, 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