{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T13:17:26Z","timestamp":1753881446478,"version":"3.41.2"},"reference-count":29,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2018R1A6A1A03025124"],"award-info":[{"award-number":["2018R1A6A1A03025124"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2020R1A2C1005345"],"award-info":[{"award-number":["2020R1A2C1005345"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,11,17]]},"abstract":"<jats:p>\n            Treatment of\n            <jats:italic>Acanthamoeba<\/jats:italic>\n            keratitis (AK) is difficult because\n            <jats:italic>Acanthamoeba<\/jats:italic>\n            cysts are resistant to drugs, and as such, successful treatment requires an effective approach that inhibits cyst formation. Histone deacetylase inhibitors (HDACis) are involved in cell proliferation, differentiation, and apoptotic cell death. In this study, the effects of HDACis such as MPK472 and KSK64 on\n            <jats:named-content content-type=\"genus-species\">Acanthamoeba castellanii<\/jats:named-content>\n            trophozoites and cysts were observed. MPK472 and KSK64 showed at least 60% amoebicidal activity against\n            <jats:italic>Acanthamoeba<\/jats:italic>\n            trophozoites at a concentration of 10\u2009\u03bcM upon 8 h of treatment.\n          <\/jats:p>","DOI":"10.1128\/aac.01506-20","type":"journal-article","created":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T12:58:11Z","timestamp":1600174691000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Application of Histone Deacetylase Inhibitors MPK472 and KSK64 as a Potential Treatment Option for\n            <i>Acanthamoeba<\/i>\n            Keratitis"],"prefix":"10.1128","volume":"64","author":[{"given":"Hae-Ahm","family":"Lee","sequence":"first","affiliation":[{"name":"Medical Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute, School of Medicine, Graduate School, Kyung Hee University, Seoul, South 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