{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:36:26Z","timestamp":1790328986917,"version":"4.1.0"},"reference-count":42,"publisher":"American Society for Microbiology","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100000038","name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["2015-05550"],"award-info":[{"award-number":["2015-05550"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            <jats:named-content content-type=\"genus-species\">Acinetobacter baumannii<\/jats:named-content>\n            is a notorious opportunistic pathogen that is prevalent mainly in hospital settings. The ability of\n            <jats:named-content content-type=\"genus-species\">A. baumannii<\/jats:named-content>\n            to adapt and to survive in a range of environments has been a key factor for its persistence and success as an opportunistic pathogen. In this study, we investigated the effect of temperature on the clinically relevant phenotypes displayed by\n            <jats:named-content content-type=\"genus-species\">A. baumannii<\/jats:named-content>\n            at 37\u00b0C and 28\u00b0C. Surface-associated motility was significantly reduced at 28\u00b0C, while biofilm formation on plastic surfaces was increased at 28\u00b0C. Decreased susceptibility to aztreonam and increased susceptibility to trimethoprim-sulfamethoxazole were observed at 28\u00b0C. No differences in virulence, as assayed in a\n            <jats:named-content content-type=\"genus-species\">Galleria mellonella<\/jats:named-content>\n            model, were observed. Proteomic analysis showed differential expression of 629 proteins, of which 366 were upregulated and 263 were downregulated at 28\u00b0C. Upregulation of the Csu and iron uptake proteins at 28\u00b0C was a key finding for understanding some of the phenotypes displayed by\n            <jats:named-content content-type=\"genus-species\">A. baumannii<\/jats:named-content>\n            at 28\u00b0C.\n          <\/jats:p>","DOI":"10.1128\/aac.01514-17","type":"journal-article","created":{"date-parts":[[2017,10,24]],"date-time":"2017-10-24T00:40:25Z","timestamp":1508805625000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":38,"title":["Effect of Incubation Temperature on Antibiotic Resistance and Virulence Factors of Acinetobacter baumannii ATCC 17978"],"prefix":"10.1128","volume":"62","author":[{"given":"P. Malaka","family":"De Silva","sequence":"first","affiliation":[{"name":"Department of Microbiology, University of Manitoba, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Chong","sequence":"additional","affiliation":[{"name":"National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh M.","family":"Fernando","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Manitoba, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrett","family":"Westmacott","sequence":"additional","affiliation":[{"name":"National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6395-7932","authenticated-orcid":false,"given":"Ayush","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Manitoba, Winnipeg, Canada"},{"name":"Manitoba Chemosensory Biology Group, University of Manitoba, Winnipeg, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1398388"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-5994.2006.01130.x"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00058-07"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.06.007"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.4315\/0362-028X.JFP-14-073"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01871"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2334-14-489"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.12.022"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1086\/313441"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1086\/529198"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu706"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v2.i12.787"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2014.10.014"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00065-13"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00944-13"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2012.00344.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiu024"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6968.12496"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1021\/pr400603f"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00963-13"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402536111"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00780-16"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2012.00148"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1021\/cb300351x"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.26541-0"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01533-08"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000834"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0137751"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.00435-12"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00096-09"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111660"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1523116113"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00116-09"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2010.07.010"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.01035-14"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/genomeA.01036-14"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep08643"},{"key":"e_1_3_3_39_2","volume-title":"M100-27","author":"Clinical and Laboratory Standards Institute","year":"2017","unstructured":"Clinical and Laboratory Standards Institute. 2017. 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