{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:23:10Z","timestamp":1788909790235,"version":"build-2803163510"},"reference-count":80,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T00:00:00Z","timestamp":1684281600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100012166","name":"MOST | National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1800903"],"award-info":[{"award-number":["2022YFD1800903"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012007","name":"Rockefeller University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012007","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunter College, CUNY"},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32072323"],"award-info":[{"award-number":["32072323"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772083"],"award-info":[{"award-number":["31772083"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Fund for Technology Innovation of Hubei Province","award":["2019AHB074"],"award-info":[{"award-number":["2019AHB074"]}]},{"name":"The Natural Science Foundation of Hubei Province","award":["2022CFB659"],"award-info":[{"award-number":["2022CFB659"]}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2023,5,17]]},"abstract":"<jats:p>\n            <jats:named-content content-type=\"genus-species\">Klebsiella pneumoniae<\/jats:named-content>\n            and\n            <jats:named-content content-type=\"genus-species\">Pseudomonas aeruginosa<\/jats:named-content>\n            are two leading causes of burn and wound infections, pneumonia, urinary tract infections, and more severe invasive diseases, which are often multidrug resistant (MDR) or extensively drug resistant. Due to this, it is critical to discover alternative antimicrobials, such as bacteriophage lysins, against these pathogens.\n          <\/jats:p>","DOI":"10.1128\/aac.01519-22","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T14:17:17Z","timestamp":1682518637000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":54,"title":["PlyKp104, a Novel Phage Lysin for the Treatment of Klebsiella pneumoniae, Pseudomonas aeruginosa, and Other Gram-Negative ESKAPE Pathogens"],"prefix":"10.1128","volume":"67","author":[{"given":"Chad W.","family":"Euler","sequence":"first","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, College of Biomedicine and Health, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China"},{"name":"Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York, USA"},{"name":"Department of Medical Laboratory Sciences, Hunter College, CUNY, New York, New York, USA"},{"name":"Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assaf","family":"Raz","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York, USA"},{"name":"Department of Medical Laboratory Sciences, Hunter College, CUNY, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anaise","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York, USA"},{"name":"Department of Medical Laboratory Sciences, Hunter College, CUNY, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Serrano","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyue","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, College of Biomedicine and Health, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China"},{"name":"Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York, USA"},{"name":"Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Andersson","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York, USA"},{"name":"Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geng","family":"Zou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, College of Biomedicine and Health, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, College of Biomedicine and Health, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent A.","family":"Fischetti","sequence":"additional","affiliation":[{"name":"Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8971-7582","authenticated-orcid":true,"given":"Jinquan","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Agricultural Microbiology, College of Biomedicine and Health, College of Food Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China"},{"name":"Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6976.2011.00269.x"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.4161\/viru.22718"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01695658"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1286-4579(00)01259-4"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2016.01.008"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.4.589"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2010.01819.x"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/338782"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11081033"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-016-7928-3"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-017-0191-3"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2016.174"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkab352"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2018.11.013"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1086\/514909"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2015.03.001"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0180121"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-019-0343-8"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics8030122"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku048"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13115"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-012-1758-8"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2693"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02794-15"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201908-1581ST"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-021-01602-z"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.03.042"},{"key":"e_1_3_4_29_2","first-page":"176","article-title":"Bacteriophages of Klebsiella spp., their diversity and potential therapeutic uses","volume":"69","author":"Herridge WP","year":"2020","unstructured":"Herridge WP, Shibu P, O\u2019Shea J, Brook TC, Hoyles L. 2020. Bacteriophages of Klebsiella spp., their diversity and potential therapeutic uses. J Med Microbiol 69:176\u2013194.","journal-title":"J Med Microbiol"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(13)70067-7"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(17)30753-3"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02252"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2019.11.001"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00483"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03277-12"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.841905"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.36849\/jdd.6363"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.01842-21"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9020074"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI136577"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2010.04931.x"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02526-12"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0108376"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.854908"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-012-4294-7"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64145-7"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2016.01402"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036991"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01379-14"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST20120209"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-011-3104-y"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2020.01.005"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0192507"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1203472109"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.04641-14"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00024-19"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-003-1522-1"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.3390\/v11030284"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics11020169"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.3390\/v12111340"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1099\/ijsem.0.003763"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.01311-20"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.59.1.1"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2016.07.008"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.614058"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkz074"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00890-10"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02972-15"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.12.97"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijfoodmicro.2021.109068"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0168615"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2672.2011.05119.x"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.enzmictec.2015.03.005"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.748718"},{"key":"e_1_3_4_75_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.637313"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1144-0"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.3390\/v12020192"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004109"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku316"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature01026"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01625-09"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01519-22","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/aac.01519-22","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,17]],"date-time":"2023-05-17T13:06:05Z","timestamp":1684328765000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/aac.01519-22"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,17]]},"references-count":80,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5,17]]}},"alternative-id":["10.1128\/aac.01519-22"],"URL":"https:\/\/doi.org\/10.1128\/aac.01519-22","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,17]]},"assertion":[{"value":"2022-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01519-22"}}