{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T03:49:49Z","timestamp":1790912989322,"version":"4.1.0"},"reference-count":22,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            The\n            <jats:italic>in vitro<\/jats:italic>\n            activities of ACH-702 and other antimicrobials against 30\n            <jats:italic>Nocardia brasiliensis<\/jats:italic>\n            isolates were tested. The MIC\n            <jats:sub>50<\/jats:sub>\n            (MIC for 50% of the strains tested) and MIC\n            <jats:sub>90<\/jats:sub>\n            values of ACH-702 were 0.125 and 0.5 \u03bcg\/ml. The same values for econazole were 2 and 4 \u03bcg\/ml. The MIC\n            <jats:sub>50<\/jats:sub>\n            and MIC\n            <jats:sub>90<\/jats:sub>\n            values of imipenem and meropenem were 64 and &gt;64 \u03bcg\/ml and 2 and 8 \u03bcg\/ml, respectively; the addition of clavulanic acid to the carbapenems had no effect.\n          <\/jats:p>","DOI":"10.1128\/aac.01520-09","type":"journal-article","created":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T01:42:20Z","timestamp":1269308540000},"page":"2191-2193","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":13,"title":["<i>In Vitro<\/i>\n            Activity of ACH-702, a New Isothiazoloquinolone, against\n            <i>Nocardia brasiliensis<\/i>\n            Compared with Econazole and the Carbapenems Imipenem and Meropenem Alone or in Combination with Clavulanic Acid"],"prefix":"10.1128","volume":"54","author":[{"given":"Lucio","family":"Vera-Cabrera","sequence":"first","affiliation":[{"name":"Laboratorio Interdisciplinario de Investigacio\u0301n Dermatolo\u0301gica, Servicio de Dermatologi\u0301a, Hospital Universitario, Monterrey, N.L., Me\u0301xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayra Paola","family":"Campos-Rivera","sequence":"additional","affiliation":[{"name":"Laboratorio Interdisciplinario de Investigacio\u0301n Dermatolo\u0301gica, Servicio de Dermatologi\u0301a, Hospital Universitario, Monterrey, N.L., Me\u0301xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy G.","family":"Escalante-Fuentes","sequence":"additional","affiliation":[{"name":"Laboratorio Interdisciplinario de Investigacio\u0301n Dermatolo\u0301gica, Servicio de Dermatologi\u0301a, Hospital Universitario, Monterrey, N.L., Me\u0301xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Pucci","sequence":"additional","affiliation":[{"name":"Achillion Pharmaceuticals, Inc., 300 George Street, New Haven, Connecticut 06511"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Ocampo-Candiani","sequence":"additional","affiliation":[{"name":"Laboratorio Interdisciplinario de Investigacio\u0301n Dermatolo\u0301gica, Servicio de Dermatologi\u0301a, Hospital Universitario, Monterrey, N.L., Me\u0301xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliverio","family":"Welsh","sequence":"additional","affiliation":[{"name":"Laboratorio Interdisciplinario de Investigacio\u0301n Dermatolo\u0301gica, Servicio de Dermatologi\u0301a, Hospital Universitario, Monterrey, N.L., Me\u0301xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.07.028"},{"key":"e_1_3_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-6968.2006.00350.x"},{"key":"e_1_3_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03028.x"},{"key":"e_1_3_1_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.65.761.190"},{"key":"e_1_3_1_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2006.07557.x"},{"key":"e_1_3_1_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01023-08"},{"key":"e_1_3_1_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.4.1476-1478.2003"},{"key":"e_1_3_1_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00148-08"},{"key":"e_1_3_1_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.1.105"},{"key":"e_1_3_1_11_2","first-page":"247","volume":"142","year":"2006","unstructured":"Fuentes, A., R. Arenas, M. Reyes, R. F. Fern\u00e1ndez, and R. Zacar\u00edas. 2006. Actinomycetoma and Nocardia sp. Report of five cases treated with imipenem or imipenem plus amikacin. Gac. Med. Mex.142:247-252.","journal-title":"Gac. Med. Mex."},{"key":"e_1_3_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1574-695X.2009.00575.x"},{"key":"e_1_3_1_13_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1167498"},{"key":"e_1_3_1_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-008-1578-x"},{"key":"e_1_3_1_15_2","first-page":"2741","volume":"61","year":"2000","unstructured":"King, D. E., R. Malone, and S. H. Lilley. 2000. New classification and update on the quinolone antibiotics. Am. Fam. Physician61:2741-2748.","journal-title":"Am. Fam. 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