{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T10:44:52Z","timestamp":1777545892036,"version":"3.51.4"},"reference-count":12,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Core-shell nanostructures with nonionic amphiphilic shells and ionic cores encapsulating gentamicin were designed for therapy against intracellular pathogens, including\n            <jats:italic>Salmonella<\/jats:italic>\n            and\n            <jats:italic>Listeria<\/jats:italic>\n            . Flow cytometry and confocal microscopy showed that their uptake into J774A.1 macrophages proceeded mainly by fluid-phase endocytosis and clathrin-mediated pathways. The nanostructures were nontoxic\n            <jats:italic>in vitro<\/jats:italic>\n            at doses of 50 to 250 \u03bcg\/ml, and they significantly reduced the amounts of intracellular\n            <jats:italic>Salmonella<\/jats:italic>\n            (0.53 log) and\n            <jats:italic>Listeria<\/jats:italic>\n            (3.16 log), thereby suggesting effective transport into the cells.\n          <\/jats:p>","DOI":"10.1128\/aac.01522-09","type":"journal-article","created":{"date-parts":[[2010,6,2]],"date-time":"2010-06-02T01:10:43Z","timestamp":1275441043000},"page":"3524-3526","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy of Amphiphilic Core-Shell Nanostructures Encapsulating Gentamicin in an\n            <i>In Vitro Salmonella<\/i>\n            and\n            <i>Listeria<\/i>\n            Intracellular Infection Model"],"prefix":"10.1128","volume":"54","author":[{"given":"A.","family":"Ranjan","sequence":"first","affiliation":[{"name":"Department of Large Animal Clinical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Pothayee","sequence":"additional","affiliation":[{"name":"Institute for Critical Technology and Applied Science"},{"name":"Macromolecules and Interfaces Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. P.","family":"Vadala","sequence":"additional","affiliation":[{"name":"Macromolecules and Interfaces Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. N.","family":"Seleem","sequence":"additional","affiliation":[{"name":"Institute for Critical Technology and Applied Science"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Restis","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Sriranganathan","sequence":"additional","affiliation":[{"name":"Institute for Critical Technology and Applied Science"},{"name":"Department of Biomedical Sciences and Pathobiology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. S.","family":"Riffle","sequence":"additional","affiliation":[{"name":"Institute for Critical Technology and Applied Science"},{"name":"Macromolecules and Interfaces Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Kasimanickam","sequence":"additional","affiliation":[{"name":"Department of Large Animal Clinical Sciences"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2008.00827.x"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2008.04.013"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10856-008-3611-2"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.2174\/156720106778559038"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.10.2511"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/35101614"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2008.04.038"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00009-09"},{"key":"e_1_3_2_10_2","first-page":"905","volume":"12","year":"2009","unstructured":"Ranjan, A., P. 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