{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:42:30Z","timestamp":1791286950292,"version":"4.1.0"},"reference-count":54,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            BAL30072 is a new monocyclic \u03b2-lactam antibiotic belonging to the sulfactams. Its spectrum of activity against significant Gram-negative pathogens with \u03b2-lactam-resistant phenotypes was evaluated and was compared with the activities of reference drugs, including aztreonam, ceftazidime, cefepime, meropenem, imipenem, and piperacillin-tazobactam. BAL30072 showed potent activity against multidrug-resistant (MDR)\n            <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n            and\n            <jats:italic>Acinetobacter<\/jats:italic>\n            sp. isolates, including many carbapenem-resistant strains. The MIC\n            <jats:sub>90<\/jats:sub>\n            s were 4 \u03bcg\/ml for MDR\n            <jats:italic>Acinetobacter<\/jats:italic>\n            spp. and 8 \u03bcg\/ml for MDR\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            , whereas the MIC\n            <jats:sub>90<\/jats:sub>\n            of meropenem for the same sets of isolates was &gt;32 \u03bcg\/ml. BAL30072 was bactericidal against both\n            <jats:italic>Acinetobacter<\/jats:italic>\n            spp. and\n            <jats:italic>P. aeruginosa<\/jats:italic>\n            , even against strains that produced metallo-\u03b2-lactamases that conferred resistance to all other \u03b2-lactams tested, including aztreonam. It was also active against many species of MDR isolates of the\n            <jats:italic>Enterobacteriaceae<\/jats:italic>\n            family, including isolates that had a class A carbapenemase or a metallo-\u03b2-lactamase. Unlike other monocyclic \u03b2-lactams, BAL30072 was found to trigger the spheroplasting and lysis of\n            <jats:italic>Escherichia<\/jats:italic>\n            <jats:italic>coli<\/jats:italic>\n            rather than the formation of extensive filaments. The basis for this unusual property is its inhibition of the bifunctional penicillin-binding proteins PBP 1a and PBP 1b, in addition to its high affinity for PBP 3, which is the target of monobactams, such as aztreonam.\n          <\/jats:p>","DOI":"10.1128\/aac.01525-09","type":"journal-article","created":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T01:42:20Z","timestamp":1269308540000},"page":"2291-2302","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":218,"title":["<i>In Vitro<\/i>\n            Properties of BAL30072, a Novel Siderophore Sulfactam with Activity against Multiresistant Gram-Negative Bacilli"],"prefix":"10.1128","volume":"54","author":[{"given":"Malcolm G. P.","family":"Page","sequence":"first","affiliation":[{"name":"Basilea Pharmaceutica International Ltd., P.O. 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