{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T01:46:06Z","timestamp":1789609566891,"version":"build-2803163510"},"reference-count":48,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:00:00Z","timestamp":1772582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT1196103"],"award-info":[{"award-number":["GNT1196103"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,3,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      Enterococcal bacteremia is a common healthcare-associated infection, associated with significant morbidity and mortality, with the emergence of vancomycin-resistant enterococci further complicating treatment and clinical outcomes. Despite this, long-term estimates of population-based incidence and antimicrobial resistance trends are limited. We aim to describe the burden of enterococcal bacteremia in Victoria, Australia (population 7.0 million), over a 35-year period. We conducted a retrospective analysis of laboratory-confirmed enterococcal bacteremia episodes voluntarily reported to the Victorian Hospital Pathogen Surveillance Scheme database from 1988 to 2022. Population-based incidence was estimated using inverse probability weighting to adjust for inconsistent hospital participation. Incidence per 10,000 hospital admissions was determined for the period 2011\u20132022. Antimicrobial resistance was calculated as the annual proportion of resistant isolates among all tested isolates. Overall, 11,157 enterococcal bacteremia episodes were identified, mainly\n                      <jats:italic toggle=\"yes\">Enterococcus faecalis<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 6,915, 61.9%) and\n                      <jats:italic toggle=\"yes\">Enterococcus faecium<\/jats:italic>\n                      (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 3,558, 31.9%). Incidence increased from &lt;3 episodes\/100,000 population in 1988 to &gt;10 by 2022. Incidence per 10,000 hospital admissions within Victoria has also increased from 2.8 in 2011 to 4 in 2022. Although\n                      <jats:italic toggle=\"yes\">E. faecalis<\/jats:italic>\n                      remained mostly susceptible to tested antibiotics,\n                      <jats:italic toggle=\"yes\">E. faecium<\/jats:italic>\n                      showed persistently high levels of vancomycin resistance, ranging from 50.7% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 69\/136) to 66.5% (\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 139\/209) over the past decade. Increasing incidence and high rates of vancomycin resistance among\n                      <jats:italic toggle=\"yes\">E. faecium<\/jats:italic>\n                      highlight the ongoing clinical and public health challenge posed by enterococcal bacteremia. Applying statistical modeling to account for variability in hospital participation improves the certainty of incidence measures and strengthens the evidence for true increase in disease burden.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01526-25","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T14:02:07Z","timestamp":1770213727000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":4,"title":["Rising burden of enterococcal bacteremia in Victoria, Australia: population-based incidence and antimicrobial resistance trends from three decades of surveillance"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-0387-6138","authenticated-orcid":false,"given":"Marwa 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