{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T04:13:30Z","timestamp":1793506410728,"version":"4.5.0"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2014,2]]},"abstract":"ABSTRACT<\/jats:title>\n \n The genus\n Nocardia<\/jats:named-content>\n has undergone rapid taxonomic expansion in recent years, and an increasing number of species are recognized as human pathogens. Many established species have predictable antimicrobial susceptibility profiles, but sufficient information is often not available for recently described organisms. Additionally, the effectiveness of sulfonamides as first-line drugs for\n Nocardia<\/jats:named-content>\n has recently been questioned. This led us to review antimicrobial susceptibility patterns for a large number of molecularly identified clinical isolates. Susceptibility results were available for 1,299 isolates representing 39 different species or complexes, including 11 that were newly described, during a 6-year study period. All tested isolates were susceptible to linezolid. Resistance to trimethoprim-sulfamethoxazole (TMP-SMX) was rare (2%) except among\n Nocardia pseudobrasiliensis<\/jats:named-content>\n (31%) strains and strains of the\n N. transvalensis<\/jats:named-content>\n complex (19%). Imipenem susceptibility varied for\n N. cyriacigeorgica<\/jats:named-content>\n and\n N. farcinica<\/jats:named-content>\n , as did ceftriaxone susceptibility of the\n N. nova<\/jats:named-content>\n complex. Resistance to more than one of the most commonly used drugs (amikacin, ceftriaxone, TMP-SMX, and imipenem) was highest for\n N. pseudobrasiliensis<\/jats:named-content>\n (100%),\n N. transvalensis<\/jats:named-content>\n complex (83%),\n N. farcinica<\/jats:named-content>\n (68%),\n N. puris<\/jats:named-content>\n (57%),\n N. brasiliensis<\/jats:named-content>\n (51%),\n N. aobensis<\/jats:named-content>\n (50%), and\n N. amikacinitolerans<\/jats:named-content>\n (43%). Thus, while antimicrobial resistance can often be predicted, susceptibility testing should still be considered when combination therapy is warranted, for less well characterized species or those with variable susceptibility profiles, and for patients with TMP-SMX intolerance.\n <\/jats:p>","DOI":"10.1128\/aac.01531-13","type":"journal-article","created":{"date-parts":[[2013,11,18]],"date-time":"2013-11-18T23:59:32Z","timestamp":1384819172000},"page":"795-800","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":167,"title":["Susceptibility Profiles of Nocardia Isolates Based on Current Taxonomy"],"prefix":"10.1128","volume":"58","author":[{"given":"Robert","family":"Schlaberg","sequence":"first","affiliation":[{"name":"ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, Salt Lake City, Utah, USA"},{"name":"Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Fisher","sequence":"additional","affiliation":[{"name":"ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, Salt Lake City, Utah, USA"},{"name":"Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley E.","family":"Hanson","sequence":"additional","affiliation":[{"name":"ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, Salt Lake City, Utah, USA"},{"name":"Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA"},{"name":"Department of Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.2.259-282.2006"},{"key":"e_1_3_3_3_2","unstructured":"DSMZ. 2013. Bacterial nomenclature up-to-date (approved lists validation lists) version June 2013. http:\/\/www.dsmz.de\/bacterial-diversity\/prokaryotic-nomenclature-up-to-date.html."},{"key":"e_1_3_3_4_2","unstructured":"EuzebyJP. 2013. List of prokaryotic names with standing in nomenclature. http:\/\/www.bacterio.net."},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.32.12.1776"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.06243-11"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1086\/657399"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00920-08"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01364-06"},{"key":"e_1_3_3_10_2","volume-title":"Approved guidelines","author":"Petti CA","year":"2008","unstructured":"PettiCABosshardPPBrandtMEClarridgeJEFeldblyumTVFoxallPFurtadoMRPaceNProcopG. 2008. Interpretive criteria for identification of bacteria and fungi by DNA target sequencing. Approved guidelines, vol 28. Clinical and Laboratory Standards Institute, Wayne, PA."},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80360-2"},{"key":"e_1_3_3_12_2","volume-title":"Approved standard\u20142nd ed","author":"Woods GL","year":"2011","unstructured":"WoodsGLBrown-ElliottBAConvillePSDesmondEPHallGSLinGPfyfferGERidderhofJCSiddiqiSHWallaceRJJrWarrenNGWitebskyFG. 2011. Susceptibility testing of mycobacteria, nocardiae, and other aerobic actinomycetes. Approved standard\u20142nd ed, vol 31. 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