{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:24:22Z","timestamp":1781087062739,"version":"3.54.1"},"reference-count":21,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T00:00:00Z","timestamp":1741132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,3,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:sec>\n            <jats:title\/>\n            <jats:p>\n              Paired baseline and post-exposure isolates from 34 patients who developed ceftolozane\u2013tazobactam (TOL-TAZ) resistance following treatment of multidrug-resistant (MDR)\n              <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n              infections were analyzed to determine if ceftolozane with an alternative \u03b2-lactamase inhibitor could restore susceptibility. The median baseline TOL-TAZ MIC was 2 mg\/L; 88% of post-exposure isolates harbored new\n              <jats:italic>ampC<\/jats:italic>\n              mutations. Median MIC fold-increase from baseline was 32-, 24-, 16-, and 6-fold for ceftolozane\u2013tazobactam, ceftolozane\u2013avibactam (AVI), ceftolozane\u2013relebactam (REL), and ceftolozane\u2013durlobactam (DUR), respectively. Enhanced ceftolozane\u2013durlobactam activity was evident in specific\n              <jats:italic>ampC<\/jats:italic>\n              mutations.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aac.01543-24","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T14:01:00Z","timestamp":1738072860000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Restoring ceftolozane susceptibility: a role for diazabicyclooctane \u03b2-lactamase inhibitors?"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-8148-8835","authenticated-orcid":false,"given":"Ava J.","family":"Dorazio","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Pittsburgh","place":["Pittsburgh, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen G.","family":"Kline","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Pittsburgh","place":["Pittsburgh, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7818-905X","authenticated-orcid":false,"given":"Kevin M.","family":"Squires","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Pittsburgh","place":["Pittsburgh, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Pogue","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, University of Michigan College of Pharmacy","place":["Ann Arbor, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7284-0103","authenticated-orcid":true,"given":"Daria","family":"Van Tyne","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Pittsburgh","place":["Pittsburgh, USA"]},{"name":"Center for Innovative Antimicrobial Therapy, University of Pittsburgh","place":["Pittsburgh, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9794-5665","authenticated-orcid":true,"given":"Ryan K.","family":"Shields","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Infectious Diseases, University of Pittsburgh","place":["Pittsburgh, USA"]},{"name":"Center for Innovative Antimicrobial Therapy, University of Pittsburgh","place":["Pittsburgh, USA"]},{"name":"Antibiotic Management Program, University of Pittsburgh Medical Center","place":["Pittsburgh, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.11.025"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae403"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00648-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciae332"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00907-24"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2018.11.001"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx424"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00084-21"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00894-20"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens10121638"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00440-23"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlad107"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix182"},{"key":"e_1_3_3_15_2","series-title":"CLSI Supplement M100 (ISBN 978-1-68440-220-5 [Print])","volume-title":"Performance standards for antimicrobial susceptibility testing","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2024","unstructured":"Clinical and Laboratory Standards Institute (CLSI). 2024. Performance standards for antimicrobial susceptibility testing. 34th ed. CLSI Supplement M100 (ISBN 978-1-68440-220-5 [Print]). 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