{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:25:27Z","timestamp":1791192327868,"version":"4.1.0"},"reference-count":62,"publisher":"American Society for Microbiology","issue":"9","license":[{"start":{"date-parts":[[2010,9,1]],"date-time":"2010-09-01T00:00:00Z","timestamp":1283299200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2010,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Monotherapy and combination therapy were compared using optimal doses of liposomal amphotericin B, micafungin, or caspofungin in\n            <jats:italic>Aspergillus fumigatus<\/jats:italic>\n            pulmonary and disseminated infections. Mice were challenged intravenously (2.8 \u00d7 10\n            <jats:sup>4<\/jats:sup>\n            to 5.7 \u00d7 10\n            <jats:sup>4<\/jats:sup>\n            conidia) or intranasally (5.8 \u00d7 10\n            <jats:sup>7<\/jats:sup>\n            conidia) with\n            <jats:italic>A. fumigatus<\/jats:italic>\n            . Drugs (5, 10, or 15 mg\/kg of body weight) were given for 3 or 6 days as single, concomitant, or sequential therapy (i.e., days 1 to 3 and then days 4 to 6). Mice were monitored for survival, and tissues were assayed for fungal burden and drug concentrations. Treatments starting 24 h postchallenge significantly prolonged survival in disseminated aspergillosis (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.002), but only liposomal amphotericin B treatments or treatments beginning with liposomal amphotericin B increased survival to 100% in the pulmonary aspergillosis model. Fungi in kidneys and spleens (disseminated) and lungs (pulmonary) were significantly decreased (\n            <jats:italic>P<\/jats:italic>\n            \u2264 0.04) by liposomal amphotericin B, liposomal amphotericin B plus echinocandin, or liposomal amphotericin B prior to echinocandin. In the disseminated infection, liposomal amphotericin B and micafungin (10 or 15 mg\/kg) had similar kidney drug levels, while in the spleen, 5 and 15 mg\/kg liposomal amphotericin B gave higher drug levels than micafungin (\n            <jats:italic>P<\/jats:italic>\n            &lt; 0.02). In the pulmonary infection, drug levels in lungs and spleen with 5-mg\/kg dosing were significantly higher with liposomal amphotericin B than with caspofungin (\n            <jats:italic>P<\/jats:italic>\n            \u2264 0.002). In summary, treatment of\n            <jats:italic>A. fumigatus<\/jats:italic>\n            infections with liposomal amphotericin B plus echinocandin or liposomal amphotericin B prior to echinocandin was as effective as liposomal amphotericin B alone, and a greater decrease in the fungal burden with liposomal amphotericin B supports using liposomal amphotericin B prior to echinocandin.\n          <\/jats:p>","DOI":"10.1128\/aac.01554-09","type":"journal-article","created":{"date-parts":[[2010,7,7]],"date-time":"2010-07-07T02:37:20Z","timestamp":1278470240000},"page":"3884-3894","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":28,"title":["Liposomal Amphotericin B and Echinocandins as Monotherapy or Sequential or Concomitant Therapy in Murine Disseminated and Pulmonary\n            <i>Aspergillus fumigatus<\/i>\n            Infections"],"prefix":"10.1128","volume":"54","author":[{"given":"Jon A.","family":"Olson","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, California State Polytechnic University, Pomona, California 91768"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ancy","family":"George","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State Polytechnic University, Pomona, California 91768"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Constable","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State Polytechnic University, Pomona, California 91768"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State Polytechnic University, Pomona, California 91768"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T.","family":"Proffitt","sequence":"additional","affiliation":[{"name":"RichPro Associates, 2095 Lavender Hill Court, Lincoln, California 95648"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill P.","family":"Adler-Moore","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, California State Polytechnic University, Pomona, California 91768"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/49.suppl_1.21"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2008.01979.x"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11115"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00699-07"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-3084(96)02652-7"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.46.9.3001-3012.2002"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-4453(97)90833-1"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23109"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2004.00254.x"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1080\/13693780500148350"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.3.1047-1050.2004"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.12.4867-4875.2005"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.4.1293-1297.2006"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1086\/514341"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp061916g"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinids\/23.3.608"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.2.422-427.2006"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1080\/mmy.39.1.55.66"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.46548-0"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.12.4.501"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg425"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020191"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.2.721-727.2005"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.3.693-715.2004"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2004.05.011"},{"key":"e_1_3_2_27_2","first-page":"17","volume":"77","year":"2006","unstructured":"Kriv\u00e1n, G., J. 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