{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:50:07Z","timestamp":1790740207078,"version":"4.1.0"},"reference-count":28,"publisher":"American Society for Microbiology","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:p>\n                    Rezafungin (CD101) is a novel echinocandin under development for once-weekly intravenous (i.v.) dosing. We evaluated the pharmacodynamics (PD) of rezafungin against 4\n                    <jats:named-content content-type=\"genus-species\">Candida tropicalis<\/jats:named-content>\n                    and 4\n                    <jats:named-content content-type=\"genus-species\">Candida dubliniensis<\/jats:named-content>\n                    strains, using the neutropenic mouse invasive candidiasis model. The area under the concentration-time curve (AUC)\/MIC was a robust predictor of efficacy (\n                    <jats:italic>R<\/jats:italic>\n                    <jats:sup>2<\/jats:sup>\n                    = 0.93 and 0.72, respectively).\n                  <\/jats:p>","DOI":"10.1128\/aac.01556-19","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T05:46:03Z","timestamp":1566971163000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":33,"title":["Determination of Pharmacodynamic Target Exposures for Rezafungin against Candida tropicalis and Candida dubliniensis in the Neutropenic Mouse Disseminated Candidiasis Model"],"prefix":"10.1128","volume":"63","author":[{"given":"Alexander J.","family":"Lepak","sequence":"first","affiliation":[{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"},{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin, Madison Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Andes","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA"},{"name":"Department of Medical Microbiology and Immunology, University of Wisconsin, Madison Wisconsin, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dky280"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02045-16"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.03.028"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2017.07.007"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2017.10.021"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01627-16"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/376906"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1086\/599039"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0127534"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-019-2497-3"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01398-10"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01079-10"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.02.016"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00029-06"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.10.003"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2012.02.001"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12539"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/mmy\/myv114"},{"key":"e_1_3_2_20_2","volume-title":"Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard","author":"Clinical and Laboratory Standards Institute","year":"2008","unstructured":"Clinical and Laboratory Standards Institute. 2008. Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard\u20143rd ed. CLSI document M27-A3. Clinical and Laboratory Standards Institute, Wayne, PA.","edition":"3"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02154-17"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a019653"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01572-18"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2016-0099"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02603-17"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02614-17"},{"key":"e_1_3_2_27_2","volume-title":"Abstr ASM Microbe, Atlanta, GA","author":"Castanheira M","year":"2018","unstructured":"Castanheira M, Messer SA, Rhomberg PR, Dietrich RR, Pfaller MA. 2018. Activity of a long-acting echinocandin rezafungin (CD101) and comparator antifungal agents tested against contemporary invasive fungal isolates: SENTRY 2016, abstr Friday-485. Abstr ASM Microbe, Atlanta, GA. American Society of Microbiology, Washington, DC."},{"key":"e_1_3_2_28_2","volume-title":"Abstr ID Week 2018, San Francisco, CA","author":"Pfaller MA","year":"2018","unstructured":"Pfaller MA, Messer SA, Rhomberg PR, Schaefer BA, Castanheira M. 2018. Activity of a long-acting echinocandin rezafungin tested against invasive fungal isolates collected worldwide, abstr 2400. Abstr ID Week 2018, San Francisco, CA. Infectious Diseases Society of America, Arlington, VA."},{"key":"e_1_3_2_29_2","volume-title":"Abstr European Congress of Clinical Microbiology and Infectious Diseases, Amsterdam, Netherlands","author":"Toth Z","year":"2019","unstructured":"Toth Z, L F, Locke JB, Kardos G, Nagy F, Kovacs R, Szekely A, Borman AM, Majoros L. 2019. Activity of rezafungin against common and rare Candida species in vitro, abstr P2161. Abstr European Congress of Clinical Microbiology and Infectious Diseases, Amsterdam, Netherlands. European Society of Clinical Microbiology and Infectious Diseases, Basel, Switzerland."}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01556-19","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01556-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T16:26:14Z","timestamp":1645460774000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01556-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11]]}},"alternative-id":["10.1128\/AAC.01556-19"],"URL":"https:\/\/doi.org\/10.1128\/aac.01556-19","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11]]},"assertion":[{"value":"2019-08-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01556-19"}}