{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:02:52Z","timestamp":1790136172559,"version":"4.0.1"},"reference-count":17,"publisher":"American Society for Microbiology","issue":"12","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100006044","name":"Astellas Pharma Europe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006044","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2020,11,17]]},"abstract":"<jats:p>\n            Intravenous administration of antibiotics is recommended during the early phase of methicillin-susceptible\n            <jats:named-content content-type=\"genus-species\">S. aureus<\/jats:named-content>\n            (MSSA) bone and joint infection (BJI). We sought to compare the plasma concentrations of cloxacillin administered alternately by continuous and intermittent infusion (CI and ItI) in patients with MSSA BJI. In this prospective crossover trial, patients were randomly assigned to receive either 3\u2009days of CI (two 75-mg\/kg 12-h cloxacillin infusions per day) and then 3\u2009days of ItI (four 37.\n          <\/jats:p>","DOI":"10.1128\/aac.01562-20","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T13:59:26Z","timestamp":1605535166000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["A Population Pharmacokinetic Analysis of Continuous Infusion of Cloxacillin during\n            <i>Staphylococcus aureus<\/i>\n            Bone and Joint Infections"],"prefix":"10.1128","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0445-5104","authenticated-orcid":false,"given":"Johan","family":"Courjon","sequence":"first","affiliation":[{"name":"Universit\u00e9 C\u00f4te d\u2019Azur, CHU Nice, Infectiologie, Nice, France"},{"name":"Universit\u00e9 C\u00f4te d\u2019Azur, 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