{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:51:37Z","timestamp":1762865497278},"reference-count":30,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Faropenem demonstrated low MICs (\u22641 \u03bcg\/ml) for all penicillin-susceptible and nonsusceptible pneumococci and exhibited very strong abilities to bind to\n            <jats:italic>Streptococcus pneumoniae<\/jats:italic>\n            penicillin-binding proteins (PBPs), except for PBP2X. The lower faropenem affinity for PBP2X did not affect MICs for any strains tested, and only imipenem had lower MICs, with much lower binding affinities for all PBPs tested, than faropenem.\n          <\/jats:p>","DOI":"10.1128\/aac.01566-08","type":"journal-article","created":{"date-parts":[[2009,2,24]],"date-time":"2009-02-24T02:10:51Z","timestamp":1235441451000},"page":"2176-2180","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":9,"title":["Binding of Faropenem and Other \u03b2-Lactam Agents to Penicillin-Binding Proteins of Pneumococci with Various \u03b2-Lactam Susceptibilities"],"prefix":"10.1128","volume":"53","author":[{"given":"Klaudia","family":"Kosowska-Shick","sequence":"first","affiliation":[{"name":"Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"McGhee","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter C.","family":"Appelbaum","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.9.2267"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2005.01334.x"},{"key":"e_1_3_2_4_2","unstructured":"Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically 2006"},{"key":"e_1_3_2_5_2","unstructured":"Performance standards for antimicrobial susceptibility testing: 17th informational supplement M100-S17. 2006"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00310-08"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2005.12.003"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000071141"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00029-07"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01529-07"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl083"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.40.4.829"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1586\/14787210.4.6.923"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.30.4.553"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.180.7.1831-1840.1998"},{"key":"e_1_3_2_16_2","first-page":"755","volume":"133","year":"1987","unstructured":"Hakenbeck, R., S. 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