{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:02:34Z","timestamp":1791237754419,"version":"4.1.0"},"reference-count":40,"publisher":"American Society for Microbiology","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            We describe the characterization of a novel CTX-M \u03b2-lactamase from\n            <jats:italic>Salmonella enterica<\/jats:italic>\n            . Four\n            <jats:italic>S. enterica<\/jats:italic>\n            isolates (three of serotype Westhampton and one of serotype Senftenberg) resistant to extended-spectrum cephalosporins (cefotaxime and ceftazidime) were recovered in 2004 from living cockles in three supermarkets located in distant geographic areas in France, which got their supplies from the same fishery. The isolates were found to produce a novel extended-spectrum \u03b2-lactamase (ESBL) belonging to the CTX-M-1 phylogenetic group and named CTX-M-53. The CTX-M-53 \u03b2-lactamase harbored the substitution Asp240Gly, like the CTX-M-15 enzyme, which is specifically implicated in a higher catalytic efficiency against ceftazidime. The\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M-53<\/jats:sub>\n            gene was located on a mobilizable 11-kb plasmid, pWES-1. The complete sequence of pWES-1 revealed the presence of a novel insertion sequence, IS\n            <jats:italic>Sen2<\/jats:italic>\n            , and an IS\n            <jats:italic>26<\/jats:italic>\n            element upstream and downstream of the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M-53<\/jats:sub>\n            gene, respectively; however, transposition assays of the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M-53<\/jats:sub>\n            gene were unsuccessful. IS\n            <jats:italic>26<\/jats:italic>\n            elements may have contributed to the acquisition of the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>CTX-M-53<\/jats:sub>\n            gene. Interestingly, the mobilization module of the pWES-1 plasmid was similar to that of quinolone resistance plasmids (carrying the\n            <jats:italic>qnrS2<\/jats:italic>\n            gene) from aquatic sources. Although belonging to two serotypes differentiated on the basis of the O-antigen structure (E1 or E4 groups), the isolates were found to be genetically indistinguishable by pulsed-field gel electrophoresis. Multilocus sequence typing showed that the isolates of serotype Westhampton had a sequence type, ST14, common among isolates of serotype Senftenberg. This is the first characterization of the CTX-M-53 ESBL, which represents an additional ceftazidime-hydrolyzing CTX-M enzyme.\n          <\/jats:p>","DOI":"10.1128\/aac.01581-08","type":"journal-article","created":{"date-parts":[[2009,3,10]],"date-time":"2009-03-10T01:23:34Z","timestamp":1236648214000},"page":"1944-1951","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":17,"title":["Novel Plasmid-Encoded Ceftazidime-Hydrolyzing CTX-M-53 Extended-Spectrum \u03b2-Lactamase from\n            <i>Salmonella enterica<\/i>\n            Serotypes Westhampton and Senftenberg"],"prefix":"10.1128","volume":"53","author":[{"given":"Benoi\u0302t","family":"Doublet","sequence":"first","affiliation":[{"name":"Institut Pasteur, Centre National de Re\u0301fe\u0301rence des Salmonella, Laboratoire des Bacte\u0301ries Pathoge\u0300nes Ente\u0301riques, Paris, France"},{"name":"INRA, UR1282, Infectiologie Animale et Sante\u0301 Publique, IASP, Nouzilly F-37380, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie A.","family":"Granier","sequence":"additional","affiliation":[{"name":"Agence Franc\u0327aise de Se\u0301curite\u0301 Sanitaire des Aliments, LERQAP, Unite\u0301 Caracte\u0301risation et Epide\u0301miologie Bacte\u0301rienne, Maisons-Alfort, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fre\u0301de\u0301ric","family":"Robin","sequence":"additional","affiliation":[{"name":"Laboratoire de Bacte\u0301riologie, CHU de Clermont-Ferrand, Clermont-Ferrand F-63003, France"},{"name":"Laboratoire de Bacte\u0301riologie, UFR de Me\u0301decine, Universite\u0301 Clermont1, JE2526 usc INRA2018, Clermont-Ferrand F-63001, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Bonnet","sequence":"additional","affiliation":[{"name":"Laboratoire de Bacte\u0301riologie, CHU de Clermont-Ferrand, Clermont-Ferrand F-63003, France"},{"name":"Laboratoire de Bacte\u0301riologie, UFR de Me\u0301decine, Universite\u0301 Clermont1, JE2526 usc INRA2018, Clermont-Ferrand F-63001, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lae\u0308titia","family":"Fabre","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Centre National de Re\u0301fe\u0301rence des Salmonella, Laboratoire des Bacte\u0301ries Pathoge\u0300nes Ente\u0301riques, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Brisabois","sequence":"additional","affiliation":[{"name":"Agence Franc\u0327aise de Se\u0301curite\u0301 Sanitaire des Aliments, LERQAP, Unite\u0301 Caracte\u0301risation et Epide\u0301miologie Bacte\u0301rienne, Maisons-Alfort, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Cloeckaert","sequence":"additional","affiliation":[{"name":"INRA, UR1282, Infectiologie Animale et Sante\u0301 Publique, IASP, Nouzilly F-37380, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franc\u0327ois-Xavier","family":"Weill","sequence":"additional","affiliation":[{"name":"Institut Pasteur, Centre National de Re\u0301fe\u0301rence des Salmonella, Laboratoire des Bacte\u0301ries Pathoge\u0300nes Ente\u0301riques, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkh300"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj2760269"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.micinf.2005.12.029"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00378-06"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.48.1.1-14.2004"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.43.11.2671"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.45.8.2269-2275.2001"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkg256"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2006.08.011"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkn339"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkl055"},{"key":"e_1_3_2_13_2","first-page":"305","year":"2002","unstructured":"Chandler, M., and J. 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