{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T18:20:25Z","timestamp":1735582825647},"reference-count":23,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2011,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            A novel gene cassette,\n            <jats:italic>aacA43<\/jats:italic>\n            , was identified in the\n            <jats:italic>aadB-aacA43-oxa10-smr2<\/jats:italic>\n            cassette array in a class 1 integron. Like related aminoglycoside-(6\u2032)-acetyltransferases, AacA43 confers clinically relevant resistance to kanamycin, tobramycin, and some less-used aminoglycosides but not to gentamicin. Although transferable on an IncL\/M plasmid,\n            <jats:italic>aacA43<\/jats:italic>\n            was identified in only two different\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Klebsiella pneumoniae<\/jats:named-content>\n            strains (14 isolates), one\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Escherichia coli<\/jats:named-content>\n            strain (2 isolates), and one\n            <jats:named-content xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" content-type=\"genus-species\" xlink:type=\"simple\">Enterobacter cloacae<\/jats:named-content>\n            strain in a survey of patients in a Sydney intensive care unit in 2004-2005.\n          <\/jats:p>","DOI":"10.1128\/aac.01582-10","type":"journal-article","created":{"date-parts":[[2011,3,22]],"date-time":"2011-03-22T04:57:09Z","timestamp":1300769829000},"page":"2979-2982","update-policy":"http:\/\/dx.doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":11,"title":["A Novel Gene Cassette,\n            <i>aacA43<\/i>\n            , in a Plasmid-Borne Class 1 Integron"],"prefix":"10.1128","volume":"55","author":[{"given":"Sally R.","family":"Partridge","sequence":"first","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology, University of Sydney, Sydney, New South Wales 2145, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lee C.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology, University of Sydney, Sydney, New South Wales 2145, Australia"},{"name":"Institute for Clinical Pathology and Medical Research, Westmead Hospital, Sydney, New South Wales 2145, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew N.","family":"Ginn","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology, University of Sydney, Sydney, New South Wales 2145, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka M.","family":"Wiklendt","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology, University of Sydney, Sydney, New South Wales 2145, Australia"},{"name":"Institute for Clinical Pathology and Medical Research, Westmead Hospital, Sydney, New South Wales 2145, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Kyme","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology, University of Sydney, Sydney, New South Wales 2145, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan R.","family":"Iredell","sequence":"additional","affiliation":[{"name":"Centre for Infectious Diseases and Microbiology, University of Sydney, Sydney, New South Wales 2145, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.42.6.1506"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.37.9.1896"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mimet.2005.02.007"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biophys.29.1.81"},{"key":"e_1_3_2_6_2","first-page":"95","article-title":"BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT","volume":"41","author":"Hall T. 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