{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T21:54:32Z","timestamp":1776376472301,"version":"3.51.2"},"reference-count":47,"publisher":"American Society for Microbiology","issue":"3","license":[{"start":{"date-parts":[[2021,2,17]],"date-time":"2021-02-17T00:00:00Z","timestamp":1613520000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673242"],"award-info":[{"award-number":["81673242"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81661138005"],"award-info":[{"award-number":["81661138005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2021,2,17]]},"abstract":"<jats:p>Widespread antimicrobial resistance encourages repurposing\/refining of nonantimicrobial drugs for antimicrobial indications. Gallium nitrate (GaNt), an FDA-approved medication for cancer-related hypercalcemia, recently showed good activity against several clinically significant bacteria.<\/jats:p>","DOI":"10.1128\/aac.01595-20","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T14:03:53Z","timestamp":1606831433000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":23,"title":["Gain-of-Function Mutations in Acid Stress Response (<i>evgS<\/i>) Protect Escherichia coli from Killing by Gallium Nitrate, an Antimicrobial Candidate"],"prefix":"10.1128","volume":"65","author":[{"given":"Jie","family":"Zeng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwen","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhou","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China"},{"name":"Department of Laboratory Medicine, The Second Hospital of Anhui Medical University, Hefei, Anhui Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihua","family":"Lv","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinzhi","family":"Feng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijie","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunxin","family":"Xue","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dai","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiabin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Drlica","sequence":"additional","affiliation":[{"name":"Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA"},{"name":"Department of Microbiology, Biochemistry &amp; Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8375-8658","authenticated-orcid":true,"given":"Xilin","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen, Fujian Province, China"},{"name":"Department of Infectious Diseases, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China"},{"name":"Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA"},{"name":"Department of Microbiology, Biochemistry &amp; Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1086\/595011"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1086\/655995"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2006.12.012"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkr262"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature17042"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.2174\/1389450116666150806124110"},{"key":"e_1_3_2_8_2","first-page":"665","article-title":"Mechanisms of therapeutic activity for gallium","volume":"50","author":"Bernstein LR","year":"1998","unstructured":"Bernstein LR. 1998. Mechanisms of therapeutic activity for gallium. Pharmacol Rev 50:665\u2013682.","journal-title":"Pharmacol Rev"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01472-15"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808608105"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1159"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30783"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2010.05.027"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00882-15"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00331-15"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01519-12"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.68.10.5619-5627.2000"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01543-13"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat7520"},{"key":"e_1_3_2_20_2","first-page":"303","article-title":"Phase I pharmacokinetic and safety study of intravenous Ganite TM (gallium nitrate) in CF","volume":"47","author":"Goss CHH","year":"2012","unstructured":"Goss CHH, Aitken ML, Caldwell E, Wilhelm E, Wolfstone A, Teresi M, Singh PK. 2012. Phase I pharmacokinetic and safety study of intravenous Ganite TM (gallium nitrate) in CF. Pediatric Pulmunol 47:303.","journal-title":"Pediatric Pulmunol"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2013.07.009"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/emph\/eoz025"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-011-1788-y"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.34"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/mmi.12704"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.80795"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007101"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2008.06146.x"},{"key":"e_1_3_2_29_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2012.08114.x"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01742-14"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00026.2013"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.708149"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dku463"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19801101)46:9<2009::AID-CNCR2820460919>3.0.CO;2-A"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197911)44:5<1722::AID-CNCR2820440528>3.0.CO;2-C"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830410403"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199142020-00007"},{"key":"e_1_3_2_38_2","first-page":"1449","article-title":"Phase I clinical studies with gallium nitrate","volume":"62","author":"Bedikian AY","year":"1978","unstructured":"Bedikian AY, Valdivieso M, Bodey GP, Burgess MA, Benjamin RS, Hall S, Freireich EJ. 1978. Phase I clinical studies with gallium nitrate. Cancer Treat Rep 62:1449\u20131453.","journal-title":"Cancer Treat Rep"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1159\/000030430"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/0470864052.ch14"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/2049-632X.12105"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/lam.12456"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(74)90463-2"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.04023-14"},{"key":"e_1_3_2_45_2","volume-title":"Experiments in molecular genetics","author":"Miller J","year":"1972","unstructured":"Miller J. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY."},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.5012\/bkcs.2008.29.2.372"},{"key":"e_1_3_2_47_2","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.4049\/jimmunol.130.4.1910","article-title":"Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation","volume":"130","author":"Bass DA","year":"1983","unstructured":"Bass DA, Parce JW, Dechatelet LR, Szejda P, Seeds MC, Thomas M. 1983. Flow cytometric studies of oxidative product formation by neutrophils: a graded response to membrane stimulation. J Immunol 130:1910\u20131917.","journal-title":"J Immunol"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(65)90035-7"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01595-20","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01595-20","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T10:18:48Z","timestamp":1697278728000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01595-20"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,17]]},"references-count":47,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,2,17]]}},"alternative-id":["10.1128\/AAC.01595-20"],"URL":"https:\/\/doi.org\/10.1128\/aac.01595-20","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,17]]},"assertion":[{"value":"2020-07-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01595-20"}}