{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:13:07Z","timestamp":1792116787462,"version":"4.4.0"},"reference-count":25,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            By studying the \u03b2-lactamase content of several\n            <jats:italic>Acinetobacter<\/jats:italic>\n            spp. isolates from Argentina, producing the expanded-spectrum \u03b2-lactamases (ESBL) VEB-1a or PER-2, a novel Ambler class A \u03b2-lactamase gene was identified. It encoded the narrow-spectrum \u03b2-lactamase SCO-1, whose activity was inhibited by clavulanic acid. SCO-1 hydrolyzes penicillins at a high level and cephalosporins and carbapenems at a very low level. \u03b2-Lactamase SCO-1 was identified from unrelated VEB-1a-positive or PER-2-positive\n            <jats:italic>Acinetobacter<\/jats:italic>\n            spp. isolates recovered from three hospitals. The\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>SCO-1<\/jats:sub>\n            gene was apparently located on a plasmid of ca. 150 kb from all cases but was not associated with any ESBL-encoding gene. The G+C content of the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>SCO<\/jats:sub>\n            gene was 52%, a value that does not correspond to that of the\n            <jats:italic>A. baumannii<\/jats:italic>\n            genome (39%). \u03b2-Lactamase SCO-1 shares 47% amino acid identity with CARB-5 and ca. 40% with the enzymes TEM, SHV, and CTX-M. A gene encoding a putative resolvase was identified downstream of the\n            <jats:italic>bla<\/jats:italic>\n            <jats:sub>SCO-1<\/jats:sub>\n            gene, but its precise way of acquisition remains to be determined.\n          <\/jats:p>","DOI":"10.1128\/aac.01600-06","type":"journal-article","created":{"date-parts":[[2007,4,10]],"date-time":"2007-04-10T00:34:03Z","timestamp":1176165243000},"page":"2179-2184","update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":47,"title":["Identification of the Novel Narrow-Spectrum \u03b2-Lactamase SCO-1 in\n            <i>Acinetobacter<\/i>\n            spp. from Argentina"],"prefix":"10.1128","volume":"51","author":[{"given":"Laurent","family":"Poirel","sequence":"first","affiliation":[{"name":"Service de Bacte\u0301riologie-Virologie, Ho\u0302pital de Bice\u0302tre, Assistance Publique\/Ho\u0302pitaux de Paris, Faculte\u0301 de Me\u0301decine Paris-Sud, Universite\u0301 Paris XI, K.-Bice\u0302tre, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ste\u0301phane","family":"Corvec","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie-Virologie, Ho\u0302pital de Bice\u0302tre, Assistance Publique\/Ho\u0302pitaux de Paris, Faculte\u0301 de Me\u0301decine Paris-Sud, Universite\u0301 Paris XI, K.-Bice\u0302tre, Paris, France"},{"name":"Laboratoire de Bacte\u0301riologie-Virologie, Hygie\u0300ne Hospitalie\u0300re, CHU, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina","family":"Rapoport","sequence":"additional","affiliation":[{"name":"Servicio Antimicrobianos, Depertamento Bacteriologia, Instituto Nacional de Enfermedades Infecciosas-ANLIS Carlos G. Malbran, Ciudad Autonoma de Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pauline","family":"Mugnier","sequence":"additional","affiliation":[{"name":"Service de Bacte\u0301riologie-Virologie, Ho\u0302pital de Bice\u0302tre, Assistance Publique\/Ho\u0302pitaux de Paris, Faculte\u0301 de Me\u0301decine Paris-Sud, Universite\u0301 Paris XI, K.-Bice\u0302tre, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Petroni","sequence":"additional","affiliation":[{"name":"Servicio Antimicrobianos, Depertamento Bacteriologia, Instituto Nacional de Enfermedades Infecciosas-ANLIS Carlos G. Malbran, Ciudad Autonoma de Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Pasteran","sequence":"additional","affiliation":[{"name":"Servicio Antimicrobianos, Depertamento Bacteriologia, Instituto Nacional de Enfermedades Infecciosas-ANLIS Carlos G. Malbran, Ciudad Autonoma de Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Faccone","sequence":"additional","affiliation":[{"name":"Servicio Antimicrobianos, Depertamento Bacteriologia, Instituto Nacional de Enfermedades Infecciosas-ANLIS Carlos G. Malbran, Ciudad Autonoma de Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Galas","sequence":"additional","affiliation":[{"name":"Servicio Antimicrobianos, Depertamento Bacteriologia, Instituto Nacional de Enfermedades Infecciosas-ANLIS Carlos G. 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