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Recent investigations have highlighted the clinical efficacy of including the oxazolidinone antibiotic linezolid in\n                      <jats:italic toggle=\"yes\">M. abscessus<\/jats:italic>\n                      combination therapies, despite moderate resistance frequently being observed in patient isolates. Even with the potential usefulness of linezolid, the mechanisms that drive linezolid resistance in\n                      <jats:italic toggle=\"yes\">M. abscessus<\/jats:italic>\n                      remain poorly understood. In several bacterial pathogens, including\n                      <jats:italic toggle=\"yes\">Mycobacterium tuberculosis<\/jats:italic>\n                      , ATP-binding cassette (ABC) family proteins of the F subtype (ABC-F) have been found to confer antibiotic resistance to ribosome-targeting antibiotics, including linezolid. Here, we identified an\n                      <jats:italic toggle=\"yes\">M. abscessus<\/jats:italic>\n                      ABC-F protein, MAB_2736c, that causes specific resistance to antibiotics that bind the 50S ribosomal subunit, including linezolid, macrolides, and chloramphenicol. These results demonstrate that targeting ABC-F proteins could help combat intrinsic resistance to several ribosome-targeting antibiotics in mycobacteria.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01605-25","type":"journal-article","created":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T15:50:56Z","timestamp":1772466656000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":0,"title":["Ribosomal protection as a linezolid resistance mechanism in\n                    <i>Mycobacterium abscessus<\/i>"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-8660-7451","authenticated-orcid":true,"given":"Tobias","family":"Funck","sequence":"first","affiliation":[{"name":"Department of Immunology and Infectious Disease, Harvard T.H. 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