{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T11:20:50Z","timestamp":1785410450654,"version":"3.56.0"},"reference-count":24,"publisher":"American Society for Microbiology","issue":"8","license":[{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T00:00:00Z","timestamp":1754438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2025,8,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>Although the treatment of pediatric hematological neoplastic diseases has improved greatly, the incidence of febrile neutropenia (FN) is more frequent and sometimes proves fatal as chemotherapy is intensified. A prospective, randomized study was performed to compare the usefulness of 2-hour drip infusions of meropenem (MEPM) and piperacillin\/tazobactam (PIPC\/TAZ) for pediatric patients with FN. Ninety-three patients with 405 febrile episodes were randomly assigned to receive MEPM or PIPC\/TAZ. MEPM 120 mg\/kg\/day was administered as a 2-hour drip infusion three times a day, whereas PIPC\/TAZ 360 mg\/kg\/day was administered as a 2-hour drip infusion four times a day. In addition, in cases that failed first-line therapy, the antibiotic administration was alternated and randomized with or without intravenous immunoglobulin (IVIG) as the second-line treatment. As the first-line treatment, MEPM was effective in 74.8% of the 206 episodes, and PIPC\/TAZ was effective in 74.9% of the 199 episodes. The total success rate in second-line treatment was 65.6%. MEPM was effective in 70.8% of the 48 episodes, and PIPC\/TAZ was effective in 60.4% of the 48 episodes. The combined first- and second-line treatment efficacy rates were 89.4% for the first-line treatment with MEPM and the second-line treatment with PIPC\/TAZ group and 91.3% in the first-line treatment with PIPC\/TAZ and second-line treatment with MEPM groups, with an overall efficacy rate of 90.4%, an excellent result. However, the efficacy of IVIG could not be proven in this study. Adolescents and young adults in the present study also presented with lower rates of antibiotic efficacy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01608-24","type":"journal-article","created":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T09:54:40Z","timestamp":1751968480000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of 2-hour drip infusions of meropenem versus piperacillin\/tazobactam for febrile neutropenia in pediatric patients"],"prefix":"10.1128","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3937-0856","authenticated-orcid":true,"given":"Ryoji","family":"Kobayashi","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024czvm93","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Hematology\/Oncology for Children and Adolescents, Sapporo Hokuyu Hospital","place":["Sapporo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirozumi","family":"Sano","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024czvm93","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Hematology\/Oncology for Children and Adolescents, Sapporo Hokuyu Hospital","place":["Sapporo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Ishigaki","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024czvm93","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Hematology\/Oncology for Children and Adolescents, Sapporo Hokuyu Hospital","place":["Sapporo, Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Matsushima","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/024czvm93","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Hematology\/Oncology for Children and Adolescents, Sapporo 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