{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T16:14:32Z","timestamp":1793463272446,"version":"4.5.0"},"reference-count":26,"publisher":"American Society for Microbiology","issue":"6","license":[{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T00:00:00Z","timestamp":1780444800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2026,6,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title\/>\n                    <jats:p>\n                      <jats:italic toggle=\"yes\">Candida albicans<\/jats:italic>\n                      remains the predominant cause of invasive candidiasis worldwide, yet comprehensive global analyses of its antifungal susceptibility trends remain scarce. In this decade-long study, we evaluated 6,342\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      isolates collected between 2015 and 2024 through the Antimicrobial Testing Leadership and Surveillance global surveillance program, representing 41 countries across four continents. Europe accounted for more than half of all isolates, followed by North America, Asia\u2013Western Pacific, and Latin America. The majority of isolates were derived from elderly and critically ill patients, particularly those hospitalized in internal medicine or intensive care units. Echinocandins and amphotericin B demonstrated sustained potency, maintaining low minimum inhibitory concentration (MIC)\n                      <jats:sub>50<\/jats:sub>\n                      \/MIC\n                      <jats:sub>90<\/jats:sub>\n                      values (0.015\u22120.03 mg\/L and 0.5\/1 mg\/L, respectively) and \u226599% susceptibility throughout the surveillance period. In contrast, fluconazole and voriconazole exhibited broader MIC distributions and a subtle upward shift in MIC\n                      <jats:sub>90<\/jats:sub>\n                      after 2022. Although global resistance rates remained below 1%, small numbers of resistant isolates were detected in several countries, including Greece (2.1%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 1), Belgium (1.1%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 4), Ireland (0.7%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2), Turkey (0.5%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 2) and the United States (0.3%,\n                      <jats:italic toggle=\"yes\">n<\/jats:italic>\n                      = 10). Temporal analysis further revealed a gradual increase in azole non\u2013wild-type isolates from 2019 to 2024, while echinocandin susceptibility remained stable. These findings confirm that\n                      <jats:italic toggle=\"yes\">C. albicans<\/jats:italic>\n                      remains broadly susceptible to frontline antifungal agents, yet the observed low-magnitude shifts and localized increases underscore the value of continued standardized surveillance and cautious, region-informed stewardship.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1128\/aac.01617-25","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T14:26:37Z","timestamp":1778595997000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":5,"title":["Global surveillance of\n                    <i>Candida albicans<\/i>\n                    : MIC distributions, resistance patterns, and temporal trends from the Antimicrobial Testing Leadership and Surveillance program (2015\u20132024)"],"prefix":"10.1128","volume":"70","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3831-2539","authenticated-orcid":false,"given":"Guiyue","family":"Cai","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05d5vvz89","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Dermatology, The First Affiliated Hospital of Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3442-9341","authenticated-orcid":false,"given":"Zhanpeng","family":"Zhang","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05d5vvz89","id-type":"ROR","asserted-by":"publisher"}],"name":"Department of Dermatology, The First Affiliated Hospital of Jinan University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof10100685"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00503-3"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S459600"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-025-10908-4"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac004"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ933"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(24)00749-7"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-5247(23)00067-8"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.00227-23"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-019-0322-2"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics13100914"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2019.09.003"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof11030232"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss7404a1"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02965-22"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/2047-783x-16-4-187"},{"key":"e_1_3_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2011.02.016"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01079-10"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/myc.12299"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2015.29"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1128\/aac.00570-24"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofy358"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2024.1456907"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03807-22"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1009564"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.3390\/jof11040284"}],"container-title":["Antimicrobial 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