{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:09Z","timestamp":1792787229494,"version":"4.5.0"},"reference-count":48,"publisher":"American Society for Microbiology","issue":"2","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1128\/ASMCopyrightv2"},{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"funder":[{"name":"Key Research and Development Program of Hubei Province","award":["2020BCA071"],"award-info":[{"award-number":["2020BCA071"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673490"],"award-info":[{"award-number":["81673490"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673524"],"award-info":[{"award-number":["81673524"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603214"],"award-info":[{"award-number":["81603214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972036"],"award-info":[{"award-number":["81972036"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2022,2,15]]},"abstract":"<jats:p>Although intra-articular vancomycin powder (VP) is sometimes applied before the closure of the incision to prevent periprosthetic joint infection (PJI) after joint replacement, the dosage, efficacy, and safety remain controversial. This study aimed to explore the dosage, efficacy, and safety of intra-articular VP in the prophylaxis of infection after total knee arthroplasty (TKA) in a rat model.<\/jats:p>","DOI":"10.1128\/aac.01641-21","type":"journal-article","created":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T15:42:27Z","timestamp":1637595747000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":15,"title":["Dosage, Efficacy, and Safety of Intra-articular Vancomycin for Prophylaxis of Periprosthetic Joint Infection Caused by Methicillin-Resistant Staphylococcus aureus after Total Knee Arthroplasty in a Rat Model"],"prefix":"10.1128","volume":"66","author":[{"given":"Jian","family":"Wei","sequence":"first","affiliation":[{"name":"Division of Joint Surgery and Sports Medicine, Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China"},{"name":"Joint Disease Research Center of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Tong","sequence":"additional","affiliation":[{"name":"Division of Joint Surgery and Sports Medicine, Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China"},{"name":"Joint Disease Research Center of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Department of Basic Medicine, Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinxian","family":"Wen","sequence":"additional","affiliation":[{"name":"Division of Joint Surgery and Sports Medicine, Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China"},{"name":"Joint Disease Research Center of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8778-1457","authenticated-orcid":true,"given":"Liaobin","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Joint Surgery and Sports Medicine, Department of Orthopedic Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China"},{"name":"Joint Disease Research Center of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"235","reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.18.00425"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2020.07.020"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00003086-199912000-00012"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2013.9999"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.artd.2018.07.011"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2017.08.007"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.5371\/hp.2018.30.1.37"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-019-05778-8"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0000000000000015"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2018.04.015"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00167-019-05498-z"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2012.03.040"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.98B1.36357"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otsr.2020.09.006"},{"key":"e_1_3_2_16_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.18.00988"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00168-11"},{"key":"e_1_3_2_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2011.12.013"},{"key":"e_1_3_2_19_2","doi-asserted-by":"publisher","DOI":"10.1086\/600884"},{"key":"e_1_3_2_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-013-0022-6"},{"key":"e_1_3_2_21_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.18.00105"},{"key":"e_1_3_2_22_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.L.01257"},{"key":"e_1_3_2_23_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.G.01237"},{"key":"e_1_3_2_24_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.00127"},{"key":"e_1_3_2_25_2","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.31526"},{"key":"e_1_3_2_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/5584_2016_157"},{"key":"e_1_3_2_27_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147447"},{"key":"e_1_3_2_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00303-21"},{"key":"e_1_3_2_29_2","first-page":"E38","article-title":"Dilute betadine lavage reduces implant-related bacterial burden in a rabbit knee prosthetic infection model","volume":"44","author":"Gilotra M","year":"2015","unstructured":"Gilotra M, Nguyen T, Jaffe D, Sterling R. 2015. Dilute betadine lavage reduces implant-related bacterial burden in a rabbit knee prosthetic infection model. Am J Orthop 44:E38\u2013E41.","journal-title":"Am J Orthop"},{"key":"e_1_3_2_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arth.2020.12.036"},{"key":"e_1_3_2_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.2.414"},{"key":"e_1_3_2_32_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2013.773121"},{"key":"e_1_3_2_33_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.00815"},{"key":"e_1_3_2_34_2","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp120568"},{"key":"e_1_3_2_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2015.01.030"},{"key":"e_1_3_2_36_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-9574LSF"},{"key":"e_1_3_2_37_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00416-17"},{"key":"e_1_3_2_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00591-16"},{"key":"e_1_3_2_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2017.04.027"},{"key":"e_1_3_2_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.47.3.581-586.1985"},{"key":"e_1_3_2_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0067628"},{"key":"e_1_3_2_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.blo.0000534692.41467.02"},{"key":"e_1_3_2_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.19.2.306"},{"key":"e_1_3_2_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2015.11.008"},{"key":"e_1_3_2_45_2","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.16.01002"},{"key":"e_1_3_2_46_2","doi-asserted-by":"publisher","DOI":"10.1242\/bio.045203"},{"key":"e_1_3_2_47_2","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.009720-0"},{"key":"e_1_3_2_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.01.018"},{"key":"e_1_3_2_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/jor.23497"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01641-21","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.asm.org\/doi\/pdf\/10.1128\/AAC.01641-21","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T18:25:58Z","timestamp":1645467958000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.asm.org\/doi\/10.1128\/AAC.01641-21"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,15]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2,15]]}},"alternative-id":["10.1128\/AAC.01641-21"],"URL":"https:\/\/doi.org\/10.1128\/aac.01641-21","relation":{},"ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,15]]},"assertion":[{"value":"2021-08-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-02-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e01641-21"}}