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This study evaluated the antiplasmodial activity of seven novel hydrazone compounds (referred to as CB compounds: CB-27, CB-41, CB-50, CB-53, CB-58, CB-59, and CB-61) against multiple stages of\n              <jats:italic>Plasmodium<\/jats:italic>\n              parasites. All CB compounds inhibited blood stage proliferation of drug-resistant or sensitive strains of\n              <jats:italic>Plasmodium falciparum<\/jats:italic>\n              in the low micromolar to nanomolar range. Interestingly, CB-41 exhibited prophylactic activity against hypnozoites and liver schizonts in\n              <jats:italic>Plasmodium cynomolgi<\/jats:italic>\n              , a primate model for\n              <jats:italic>Plasmodium vivax<\/jats:italic>\n              . Four CB compounds (CB-27, CB-41, CB-53, and CB-61) inhibited\n              <jats:italic>P. falciparum<\/jats:italic>\n              oocyst formation in mosquitoes\n              <jats:italic>,<\/jats:italic>\n              and five CB compounds (CB-27, CB-41, CB-53, CB-58, and CB-61) hindered the\n              <jats:italic>in vitro<\/jats:italic>\n              development of\n              <jats:italic>Plasmodium berghei<\/jats:italic>\n              ookinetes. The CB compounds did not inhibit the activation of\n              <jats:italic>P. berghei<\/jats:italic>\n              female and male gametocytes\n              <jats:italic>in vitro<\/jats:italic>\n              . Isobologram assays demonstrated synergistic interactions between CB-61 and the FDA-approved antimalarial drugs, clindamycin and halofantrine. Testing of six CB compounds showed no inhibition of\n              <jats:italic>Plasmodium<\/jats:italic>\n              glutathione S-transferase as a putative target and no cytotoxicity in HepG2 liver cells. CB compounds are promising candidates for further development as antimalarial drugs against multidrug-resistant parasites, which could also prevent malaria transmission.\n            <\/jats:p>\n          <\/jats:sec>","DOI":"10.1128\/aac.01643-23","type":"journal-article","created":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T13:00:28Z","timestamp":1713531628000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":6,"title":["Novel hydrazone compounds with broad-spectrum antiplasmodial activity and synergistic interactions with antimalarial drugs"],"prefix":"10.1128","author":[{"given":"Ang\u00e9lica M.","family":"Rosado-Qui\u00f1ones","sequence":"first","affiliation":[{"name":"Department of Microbiology and Medical Zoology, University of Puerto Rico School of Medicine, San Juan, Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilee 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