{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T22:19:56Z","timestamp":1778105996257,"version":"3.51.4"},"reference-count":36,"publisher":"American Society for Microbiology","issue":"4","license":[{"start":{"date-parts":[[2018,4,1]],"date-time":"2018-04-01T00:00:00Z","timestamp":1522540800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.asm.org\/non-commercial-tdm-license"}],"content-domain":{"domain":["journals.asm.org"],"crossmark-restriction":true},"short-container-title":["Antimicrob Agents Chemother"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>\n            Bacterial sepsis is a major cause of morbidity and mortality in neonates, especially those involving methicillin-resistant\n            <jats:named-content content-type=\"genus-species\">Staphylococcus aureus<\/jats:named-content>\n            (MRSA). Guidelines by the Infectious Diseases Society of America recommend the vancomycin 24-h area under the concentration-time curve to MIC ratio (AUC\n            <jats:sub>24<\/jats:sub>\n            \/MIC) of &gt;400 as the best predictor of successful treatment against MRSA infections when the MIC is \u22641 mg\/liter. The relationship between steady-state vancomycin trough concentrations and AUC\n            <jats:sub>24<\/jats:sub>\n            values (mg\u00b7h\/liter) has not been studied in an Asian neonatal population. We conducted a retrospective chart review in Singapore hospitals and collected patient characteristics and therapeutic drug monitoring data from neonates on vancomycin therapy over a 5-year period. A one-compartment population pharmacokinetic model was built from the collected data, internally validated, and then used to assess the relationship between steady-state trough concentrations and AUC\n            <jats:sub>24<\/jats:sub>\n            . A Monte Carlo simulation sensitivity analysis was also conducted. A total of 76 neonates with 429 vancomycin concentrations were included for analysis. Median (interquartile range) was 30 weeks (28 to 36 weeks) for postmenstrual age (PMA) and 1,043 g (811 to 1,919 g) for weight at the initiation of treatment. Vancomycin clearance was predicted by weight, PMA, and serum creatinine. For MRSA isolates with a vancomycin MIC of \u22641, our major finding was that the minimum steady-state trough concentration range predictive of achieving an AUC\n            <jats:sub>24<\/jats:sub>\n            \/MIC of &gt;400 was 8 to 8.9 mg\/liter. Steady-state troughs within 15 to 20 mg\/liter are unlikely to be necessary to achieve an AUC\n            <jats:sub>24<\/jats:sub>\n            \/MIC of &gt;400, whereas troughs within 10 to 14.9 mg\/liter may be more appropriate.\n          <\/jats:p>","DOI":"10.1128\/aac.01647-17","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T11:28:33Z","timestamp":1516274913000},"update-policy":"https:\/\/doi.org\/10.1128\/asmj-crossmark-policy-page","source":"Crossref","is-referenced-by-count":42,"title":["Evaluating the Relationship between Vancomycin Trough Concentration and 24-Hour Area under the Concentration-Time Curve in Neonates"],"prefix":"10.1128","volume":"62","author":[{"given":"Sheng-Hsuan","family":"Tseng","sequence":"first","affiliation":[{"name":"Department of Pharmacy, National University of Singapore, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuan Poh","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, KK Women's and Children's Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng Cai","family":"Tang","sequence":"additional","affiliation":[{"name":"Lilly-NUS Centre for Clinical Pharmacology Pte, Ltd., Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sing Teang","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Singapore General Hospital, Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul Chi-Lui","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, National University of Singapore, 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